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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
UnknownExtended SIR Prediction of the Epidemics Trend of COVID-19 in Italy and Compared With Hunan, China.
Not available
S-EPMC7218168 | biostudies-literature
ProteomicsStructural insights into dynamics of the BMV TLS aminoacylation
We performed Biotinylated RNA pull-down coupled with mass spectrometry, which enables the identification of TLS-binding proteins. Using in vitro synthesized BMV TLS and protein extracts derived from Nicotiana tabacum L.'s leaves, mass spectrometry results demonstrated the enrichment of ribosome-asso...
ORGANISM(S): 'nicotiana Tabacum' Yellowing Phytoplasma 
2024-11-13 | PXD057815 |
UnknownA Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.
Not available
S-EPMC7121492 | biostudies-literature
TranscriptomicsEffect of BMP4 and noggin on gene expression in murine R1 ES cells
To confirm that the SMAD1/5- and SMAD4-associated genes are direct transcriptional regulators in mESCs in response to BMP, we treated undifferentiated R1 ES cells with BMP4 or with the BMP4 antagonist noggin, which can inhibit BMP signaling effectively for 4 h. Undifferentiated R1 ES cells were trea...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-20527 | biostudies-arrayexpress
TranscriptomicsBone marrow gene expression of pediatric acute lymphoblastic leukemia (ALL)
Pediatric acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Subtype classification can be also achieved through gene expression profiling. However, how to apply such classifiers to a single patient and correctly diagnose the di...
ORGANISM(S): Homo sapiens 
2009-08-19 | E-GEOD-17703 | biostudies-arrayexpress
ProteomicsProteome profile dataset of IDA treatment
To study the mechanism underlying IDA-induced anti-tumor activity for Abi resistance, LNCaP-Abi cells were treated with Abi alone and in combination with IDA for 24 h. Protein profiles were determined by mass spectrometry
ORGANISM(S): Homo Sapiens 
2022-01-12 | PXD030905 |
ProteomicsNuclear condensation of CDYL links histone crotonylation and cystogenesis in autosomal dominant polycystic kidney disease
We identify the Kcr sites on histones that are targeted by CDYL in ADPKD cells (WT9-12 cells). We chose to knock out CDYL in WT 9-12 cells (CDYL KO) through CRISPR/Cas9-mediated gene editing to increase the overall levels of histone Kcr. We quantified Kcr modifications on different histone residues ...
ORGANISM(S): Homo Sapiens 
2022-01-17 | PXD031029 |
Proteomicsimmunoprecipitation-mass spectrometry related to rice stripe virus SP
immunoprecipitation-mass spectrometry related to rice stripe virus SP
ORGANISM(S): Oryza Sativa 
2025-05-07 | PXD063713 |
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