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MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
ProteomicsTargeted degradation of extracellular mitochondrial aspartyl-tRNA synthetase modulates immune responses in bacterial pneumonia
The severity of bacterial pneumonia can be worsened by impaired innate immunity resulting in ineffective pathogen clearance. Here We describe a mitochondrial protein, aspartyl-tRNA synthetase (DARS2), which is released in circulation during bacterial pneumonia in humans and displays intrinsic innate...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050224 | Pride
Inflammation Pneumonia Dars2 
ProteomicsMicroID: A Novel Biotin Ligase Enables Rapid Proximity Ligation Proteomics
Identifying protein-protein interactions is central to dissecting signaling and regulatory processes in cells. BioID is a proximity ligation method that uses a promiscuous biotin ligase to detect protein-protein interactions in cells in a highly reproducible manner. Recent advancements in proximity ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031146 | Pride
Proximity ligation  bioid  turboid  organelle  mass spectrometry  microid 
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
ProteomicsProteomic analysis of Bombus terrestris queen haemolymph
Enabled by recently available genomic resources for bumblebees, nano LC-MS/MS based proteomics was conducted to characterise the queen haemolymph proteome. The resulting mass spectrometry data were also utilised in a proteogenomic capacity to identify proteins missing from official gene sets and to ...
ORGANISM(S): Bombus terrestris (Buff-tailed bumblebee) (Apis terrestris) 
2015-02-24 | PXD001644 | Pride
Bumblebee Proteogenomics Haemolymph profile Queen 
UnknownDevelopment and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
Not available
S-EPMC4380415 | biostudies-literature
UnknownCausal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.
Not available
S-EPMC3564800 | biostudies-literature
UnknownA single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background.
Not available
S-EPMC3003749 | biostudies-literature
UnknownVestibular Rehabilitation for Peripheral Vestibular Hypofunction: An Updated Clinical Practice Guideline From the Academy of Neurologic Physical Therapy of the American Physical Therapy Association.
Not available
S-EPMC8920012 | biostudies-literature
MetabolomicsLipid biomarkers for algal resistance to viral infection in the ocean

Marine viruses play a key role in regulating phytoplankton populations, greatly affecting the biogeochemical cycling of major nutrients in the ocean. Resistance to viral infection has been reported for various phytoplankton species under laboratory conditions. Nevertheless, the occurrence of resi...

2023-06-12 | MTBLS3323 | MetaboLights
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