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ProteomicsA CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
Controlled gene expression is achieved through the intricate regulation of Pol II progression through transcription-cycle checkpoints. While the contribution of CDK9 for Pol II pause-release is well established, the requirement for other CDKs has not been fully elucidated. Here we propose a new role...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD066230 | Pride
Cdk11 Transcription Pause-release Leukaemia 
ProteomicsCDK13 cooperates with CDK12 to control global RNA polymerase II processivity
The RNA polymerase II (POLII) driven transcription cycle is tightly regulated at distinct checkpoints through cyclin dependent kinases (CDKs) and their cognate Cyclins. The molecular events underpinning transcriptional elongation and processivity and CDK-Cyclins involved remain poorly understood. Us...
ORGANISM(S): Homo sapiens (Human) 
2020-04-30 | PXD015453 | Pride
Cdk13 Cdk12 Phosphoproteomics Polymerase 
TranscriptomicsHDAC Inhibitors induce tumor cell-selective pro-apoptotic transcriptional responses.
The identification of recurrent somatic mutations in genes encoding epigenetic enzymes, coupled with biochemical studies demonstrating aberrant recruitment of epigenetic enzymes such as histone deacetylases (HDACs) and histone methyltransferases (HMTs) to promoter regions through association with on...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-43010 | biostudies-arrayexpress
ProteomicsA PP2A-Integrator complex fine-tunes transcription by opposing CDK9
Gene expression by RNA Polymerase II (RNAPII) is tightly controlled by Cyclindependent kinases (CDKs) at discrete checkpoints during the transcription cycle. The RNAPII pausing checkpoint, engaged after transcription initiation, is controlled by CDK9 to regulate transcription in metazoans. We discov...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2022-08-12 | PXD022962 | Pride
Cdk9 Transcription Pp2a 
UnknownTargeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas.
Not available
S-EPMC8160501 | biostudies-literature
UnknownPrinciples of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision.
Not available
S-EPMC11654686 | biostudies-literature
UnknownProbiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: a pilot trial.
Not available
S-EPMC4970233 | biostudies-literature
TranscriptomicsGenome wide expression analysis of BET inhibitor resistance
Bromodomain and Extra Terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a new therapeutic paradigm by directly targeting epigenetic readers. Early clinical trials have shown significant promise especially in acute myeloid leukaemia (AML)3; therefore the evaluation ...
ORGANISM(S): Mus musculus 
2015-09-15 | E-GEOD-63575 | biostudies-arrayexpress
TranscriptomicsExpression data from BRAFV600E A375 melanoma cells treated with vehicle or vemurafenib
Vemurafenib is a BRAF inhibitor with specificity for the most common BRAF mutant encountered in melanomas (BRAFV600E). Vemurafenib suppresses the proliferation of BRAF mutant human melanoma cells by suppressing downstream activation of the MEK/ERK mitogen activated protein kinases. We used microarra...
ORGANISM(S): Homo sapiens 
2014-05-20 | E-GEOD-42872 | biostudies-arrayexpress
UnknownAntigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance.
Not available
S-EPMC8119420 | biostudies-literature
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