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ProteomicsCDK13 cooperates with CDK12 to control global RNA polymerase II processivity
The RNA polymerase II (POLII) driven transcription cycle is tightly regulated at distinct checkpoints through cyclin dependent kinases (CDKs) and their cognate Cyclins. The molecular events underpinning transcriptional elongation and processivity and CDK-Cyclins involved remain poorly understood. Us...
ORGANISM(S): Homo sapiens (Human) 
2020-04-30 | PXD015453 | Pride
Cdk13 Cdk12 Phosphoproteomics Polymerase 
ProteomicsA PP2A-Integrator complex fine-tunes transcription by opposing CDK9
Gene expression by RNA Polymerase II (RNAPII) is tightly controlled by Cyclindependent kinases (CDKs) at discrete checkpoints during the transcription cycle. The RNAPII pausing checkpoint, engaged after transcription initiation, is controlled by CDK9 to regulate transcription in metazoans. We discov...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2022-08-12 | PXD022962 | Pride
Cdk9 Transcription Pp2a 
ProteomicsA CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
Controlled gene expression is achieved through the intricate regulation of Pol II progression through transcription-cycle checkpoints. While the contribution of CDK9 for Pol II pause-release is well established, the requirement for other CDKs has not been fully elucidated. Here we propose a new role...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD066230 | Pride
Cdk11 Transcription Pause-release Leukaemia 
TranscriptomicsExpression profiling in Wild-type and C-JUN knockout MEFs treated with IFNgamma and cycloheximide
STAT1 is the major transcription factor (TF) driving response to exposure to IFNg. C-JUN is a TF which has been shown to bind with STAT1 and act as a partner TF. We have expression profiled WT and CJUN-/- MEFs in order to determine the set of IFNg genes regulated by STAT1 and C-JUN. This study was d...
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-26205 | biostudies-arrayexpress
TranscriptomicsHDAC Inhibitors induce tumor cell-selective pro-apoptotic transcriptional responses.
The identification of recurrent somatic mutations in genes encoding epigenetic enzymes, coupled with biochemical studies demonstrating aberrant recruitment of epigenetic enzymes such as histone deacetylases (HDACs) and histone methyltransferases (HMTs) to promoter regions through association with on...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-43010 | biostudies-arrayexpress
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