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TranscriptomicsCombining Next-Generation Sequencing and Microarray Technology into a Transcriptomics Approach for the Non-Model Organism Chironomus riparius
Whole-transcriptome gene-expression analyses are commonly performed in species that have a sequenced genome and for which microarrays are commercially available. To do such analyses in species with no or limited genome data, i.e. non-model organisms, necessary transcriptomics resources, i.e. an anno...
ORGANISM(S): Anopheles gambiae 
2014-05-19 | E-GEOD-53449 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary nasal epithelium exposed to house dust mite extract shows activated expression in allergics
Response to allergen was studied in epithelial cells derived from allergic pantients and from healthy controls. Cells were cultured after isolation from a nasal biopsy. Cells were exposed to Housed dust mite or vessel (saline); Microarray data was analysed using bioinformatics and biostaistics. We c...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9150 | biostudies-arrayexpress
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: cadmium
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-05-05 | E-GEOD-21010 | biostudies-arrayexpress
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: atrazine
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-03-23 | E-GEOD-21008 | biostudies-arrayexpress
TranscriptomicsDissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.
Under REACH, the European Community Regulation on chemicals, the testing strategy for carcinogenicity is generally based on in vitro and in vivo genotoxicity assays. Given that non-genotoxic carcinogens are negative for genotoxicity, this class of carcinogens will not be detected. Therefore, alterna...
ORGANISM(S): Mus musculus 
2012-06-25 | E-GEOD-35058 | biostudies-arrayexpress
ProteomicsIntegrative analysis of proteome and transcriptome dynamics during Bacillus subtilis spore revival
Description Bacillus subtilis forms highly resistant, metabolically inactive spores upon nutrient limitation. These endospores pose challenges to the food and medical sectors. Spores reactivate their metabolism upon contact with germinants through germination and outgrowth, and then develop into ve...
ORGANISM(S): Bacillus Subtilis (ncbitaxon:1423) 
2020-04-02 | MSV000085217 | MassIVE
TranscriptomicsLinking toxicant physiological mode of action with induced gene expression changes in Caenorhabditis elegans: fluoranthene
Physiologically based modelling using DEBtox (dynamic energy budget in toxicology) and transcriptional profiling were used in Caenorhabditis elegans to identify how physiological modes of action, as indicated by effects on system level resource allocation were associated with changes in gene express...
ORGANISM(S): Caenorhabditis elegans 
2010-05-05 | E-GEOD-21011 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type, p53 Ser389 phosphorylation site point mutant and p53 knock-out mouse embryonic fibroblasts after exposure to UV radiation for different lengths of time
Comparison of responses of mouse wild-type, p53 Ser389 phosphorylation site point mutant and full knock-out mutant MEF cells to UV-C-radiation in time
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1397 | biostudies-arrayexpress
TranscriptomicsDifferences in gene expression profiles between human preimplantation embryos cultured in two different IVF culture media
Study question: Is gene expression in human preimplantation embryos affected by medium used for culturing embryos during an IVF treatment? Summary answer: Six days of in vitro culture of human preimplantation embryos resulted in a medium-dependent expression level of genes involved in apoptosis, pr...
ORGANISM(S): Homo sapiens 
2015-07-08 | E-MTAB-3405 | biostudies-arrayexpress
TranscriptomicsGene expression patterns and life cycle responses of toxicant exposed chironomids
Cellular stress responses are frequently presumed to be more sensitive than traditional ecotoxicological life cycle endpoints such as survival and growth. Yet, the focus to reduce test duration and to generate more sensitive endpoints has caused transcriptomics studies to be performed at low doses d...
ORGANISM(S): Chironomus riparius 
2013-08-08 | E-GEOD-40010 | biostudies-arrayexpress
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