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MetabolomicsCollagen induced arthritis in dba/1j mice associates with oxylipin changes in plasma
Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range of diseases such as rheumatoid arthritis (RA). The purpose of this research was to study differences in oxylipin levels between a widely used collagen-induced arthritis (CI...
2015-11-04 | MTBLS243 | MetaboLights
MetabolomicsMetabolic characterization of the natural progression of chronic hepatitis B (Oxylipin assay)
Background: Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive liver diseases. The confinement of HBV replication to the liver, which also acts as the central hub for metabolic and nutritional regulation, e...
2016-06-06 | MTBLS253 | MetaboLights
MetabolomicsFetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell’s...
2018-06-06 | MTBLS449 | MetaboLights
UnknownOxidative damage to epigenetically methylated sites affects DNA stability, dynamics and enzymatic demethylation.
Not available
S-EPMC6237784 | biostudies-literature
ProteomicsMS analysis of photocrosslink adducts for the mapping of interaction sites of selective engineered PSD-95 PDZ domain ligands
Designing highly specific modulators of protein-protein interactions (PPIs) is especially challenging in the context of multiple paralogs and conserved interaction surfaces. In this case, direct generation of selective and competitive inhibitors is hindered by high similarity within the evolutionary...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-11-12 | PXD015366 | Pride
Engineered ligand/pdz domains/photocrosslinking/p-azidophenylalanine 
ProteomicsTargeting APEX2 to the mRNA encoding fatty acid synthase β in yeast identifies proteins that bind and control its translational efficiency in the cell cycle
To understand how the translation of FAS1, encoding fatty acid synthase, peaks late in the cell cycle, we identified proteins that bind the FAS1 transcript in a cell cycle-dependent manner. We used dCas13d-APEX2 fusions to target FAS1 and label nearby proteins, which were then identified by mass spe...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-05-24 | PXD041908 | Pride
Yeast  lc-ms/ms  proximity labeling 
ProteomicsQuantitative temporal proteomic analysis of modified vaccinia Ankara, a mpox vaccine
Modified vaccinia Ankara (MVA) immunisation is being deployed to curb the current outbreak of mpox in multiple countries1. Originally authorized for vaccination against smallpox, MVA is a vaccinia virus (VACV) strain that does not replicate in human cells or cause serious adverse events. Here, we co...
ORGANISM(S): Homo sapiens (Human) Modified Vaccinia Ankara virus 
2023-10-11 | PXD039034 | Pride
Modified vaccinia ankara  vaccinia virus  mpox  monkeypox virus  innate immunity  immune evasion  host-pathogen interaction  proteomics 
ProteomicsHuman cytomegalovirus protein pUL36: a dual cell death pathway inhibitor
Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of intrinsic, innate and adaptive viral immune evasion. Here, we employ multiplexed tandem mass tag-based proteomics to characterise host proteins targeted for degradation late during HCMV infection. This approach revealed th...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2020-07-10 | PXD017279 | Pride
Human cytomegalovirus  cell death  necroptosis  host-pathogen interaction  quantitative proteomics  protein degradation  proteasome  mlkl 
ProteomicsACSS2 Upregulation Enhances Neuronal Resilience to Aging and Neurodegeneration
Epigenetic mechanisms, including histone acetylation, play a key role in learning and memory, with recent evidence of a role in neuronal function in Alzheimer’s disease and Related Dementia (ADRD). Acetyl-CoA sythetase 2 (ACSS2) is central to epigenetics and gene regulation, particularly in neurons,...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD048769 | Pride
Acss2 Aging Neuron Neurodegeneration 
ProteomicsMapping physiological ADP-ribosylation using Activated Ion Electron Transfer Dissociation (AI-ETD)
ADP-ribosylation (ADPr) is a post-translational modification that plays pivotal roles in a wide range of cellular processes. Mass spectrometry (MS)-based analysis of ADPr under physiological conditions, without relying on genetic or chemical perturbation, has been hindered by technical limitations. ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-23 | PXD017417 | Pride
Activated ion electron transfer dissociation Post-translational modification Adpr Ptm Parp Ai-etd Adp-ribosylation 
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