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ProteomicsFumarate hydratase suppresses glioblastoma progression via a TRIM17-RRN3 proteostatic axis
Emerging evidence indicates that metabolic reprogramming plays a pivotal role in glioblastoma (GBM) progression. Here, we report that the expression of fumarate hydratase (FH) is significantly reduced in GBM patient samples. FH overexpression suppresses the viability, migration, and invasion of GBM ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD067085 | Pride
Human Succination U87 Gbm Lc-ms/ms 
ProteomicsHSPA4 restrains transferrin in dopaminergic neurons to attenuate ferroptosis in a Parkinson’s disease model
Heat shock protein A4 (HSPA4) is a molecular chaperone belonging to the heat shock protein 70 (HSP70) family. This study aims to investigate the antiferroptotic effects of HSPA4 in a Parkinson’s disease (PD) model and explore the underlying mechanisms. Here we show that HSPA4 overexpression reduces ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD067550 | Pride
Dopaminergic neurons Hspa4 Parkinson’s disease Ferroptosis Transferrin 
ProteomicsAn essential maternal PADI6-UHRF1-UBE2D (MPU) complex regulates protein ubiquitination during oocyte maturation and embryogenesis
100 WT or Padi6Null MII oocytes for MS samples from three independent experiments and IP samples in 500 MII oocytes from one experiment were used for Mass spectrometry analysis.
ORGANISM(S): Mus Musculus 
2025-01-25 | PXD060230 |
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