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TranscriptomicsTranscription profiling of mouse liver from JNK knocked down animals
Liver-specific Knockdown of JNK1 Up-regulates Proliferator-activated Receptor Coactivator 1 and Increases Plasma Triglyceride despite Reduced Glucose and Insulin Levels in Diet-induced Obese Mice. The c-Jun N-terminal kinases (JNKs) have been implicated in the development of insulin resistance, dia...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7648 | biostudies-arrayexpress
UnknownPhase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors.
Not available
S-EPMC5978471 | biostudies-literature
TranscriptomicsRegulation of Pkm2 by miR-122.
The study identified Pkm2 to be highly expressed in human embryonic stem cells and hepatocellular carcinoma cells, and targeted by a microRNA that is highly expressed in human primary hepatocytes. Gene expression patterns were compared from total RNA obtained from human embryonic stem cells, human p...
ORGANISM(S): Homo sapiens 
2014-06-08 | E-GEOD-29907 | biostudies-arrayexpress
ProteomicsA de novo mutation in /ITPR3/ causes combined immunodeficiency
This study reports two unrelated patients with a combined immunodeficiency. Whole-exome sequencing of both patients, their healthy parents and siblings identified in both families a /de novo/ missense variant in /ITPR3/ (NM_002224.3:c.7570C>T, p.Arg2524Cys). While the mRNA level in patients remained...
ORGANISM(S): Homo sapiens (Human) 
2024-06-18 | PXD038284 | Pride
Shotgun proteomics Rnaseq Itpr3 mutation Immunophenotying 
TranscriptomicsCIT_VADS_BW_OMICS
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net); Integrative study based on 89 patients with Head and Neck Squamous Cell Carcinoma (HNSCC); 89 Affymetrix HG-U133 Plus 2.0 GeneChips arrays; 88 samples on HumanCNV370-Quad Ge...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-MTAB-1328 | biostudies-arrayexpress
ProteomicsRegulated local synthesis of ribosomal proteins maintains ribosome function in axons
Ribosome assembly occurs mainly in the nucleolus yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies. Here, we report a physical and functional interaction between locally synthesized RPs and ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-12-09 | PXD015574 | Pride
Ribosomes Sucrose density gradient fractionation Axon 
ProteomicsSILAC-labeled proteins in ribosome samples
we developed a novel method combining axon-pSILAC17 with axonal ribosome purification. In this method, we first labeled newly synthesized proteins with heavy amino acids (AAs) in somaless axons cultured in a Boyden chamber. Approximately 2000 eyes were cultured for each experiment to obtain sufficie...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2019-12-09 | PXD011032 | Pride
Xenopus laevis Axon Ribosome Silac 
GenomicsThe oncogenic microRNA hsa-mir-155-5p targets the transcription factor ELK3 and links it to the hypoxia response and the Hypoxia Inducible Factor HIF1M-NM-1
The molecular response to hypoxia is a critical cellular process implicated in cancer, and a target for drug development. The activity of the major player, HIF1M-NM-1,M-BM- is regulated at different levels, including the transcriptional level by the Ets factor ELK3. The molecular mechanisms of this ...
ORGANISM(S): Homo sapiens 
2014-12-04 | E-GEOD-60156 | biostudies-arrayexpress
TranscriptomicsThe dynamic translatome of retinal ganglion cell axons during assembly and maintenance of the mouse visual system
Local mRNA translation mediates the adaptive responses of axons to extrinsic signals but direct evidence that it occurs in mammalian CNS axons in vivo is scant. We developed an axon-TRAP-RiboTag approach in mouse that allows deep-sequencing analysis of ribosome-bound mRNAs in the retinal ganglion ce...
ORGANISM(S): Mus musculus 
2016-06-16 | E-GEOD-79352 | biostudies-arrayexpress
Genomics200PT.bam - samples
200PT : WG Aligned Sequence (bam)/ Aligned WG sequence data in this dataset are from CPCGene Tumour/Normal Pairs used in the 200PT Study
EGAD00001004061 | EGA
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