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GenomicsThe characteristics of genome-wide DNA methylation in naM-CM-/ve CD4+ T cells of patients with psoriasis and atopic dermatitis
Psoriasis and atopic dermatitis (AD) are characterized by polarized CD4+ T cell responses. During the polarization of naM-CM-/ve CD4+ T cells, DNA methylation plays an important role in the regulation of gene transcription. In this study, we profiled the genome-wide DNA methylation status of naM-CM-...
ORGANISM(S): Homo sapiens 
2012-03-17 | E-GEOD-35582 | biostudies-arrayexpress
ModelsPark2019 - IL7 receptor signaling in T cells
This model is an attempt to provide a mathematical description of IL-7 dependent T cell homeostasis at the molecular and cellular level, with inclusion of gamma-chain and ligand binding in the context of receptors for IL-7 and IL-15 receptors.
2024-09-02 | BIOMD0000000803 | BioModels
ProteomicsA sensitive S-trap-based approach to the analysis of T-cell raft proteome
The development of sensitive technologies for T cell-raft proteomics is highly challenging. We explored an innovative strategy, based on suspension trapping (S-trap) sample preparation. Mouse splenocytes were subjected to negative immunoselection for T cell preparation. Rafts were isolated by a dete...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-08-13 | PXD016476 | Pride
T cell Optiprep Raftomics Fasp S-trap Detergent-free 
TranscriptomicsCX3CR1/Fractalkine receptor expression separates memory CD8+ T cells with distinct functional profiles (RNA-seq)
Memory T cells are important for protective immunity against infectious microorganisms. Such protection is achieved by cooperative action of memory T cell populations that differ in their tissue localization and functionality. We report on the identification of the fractalkine receptor CX3CR1 as mar...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-63144 | biostudies-arrayexpress
TranscriptomicsCX3CR1/Fractalkine receptor expression separates memory CD8+ T cells with distinct functional profiles (expression)
Memory T cells are important for protective immunity against infectious microorganisms. Such protection is achieved by cooperative action of memory T cell populations that differ in their tissue localization and functionality. We report on the identification of the fractalkine receptor CX3CR1 as mar...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-63118 | biostudies-arrayexpress
GenomicsMapping of Notch1 binding sites in a mouse immature T cell line
We used an immature mouse T cell line engineered to express a biotinylated form of the cleaved form of Notch1 (ICN1). ICN1-bound sites were precipitated with streptavidin-coated beads and subjected to ChIP-sequencing. Beko cells correspond to a spontaneous T lymphoma immature cell line derived from ...
ORGANISM(S): Mus musculus 
2014-04-02 | E-GEOD-46114 | biostudies-arrayexpress
GenomicsMapping of Ikaros and RBPJ binding sites in the mouse T cell leukemia cell line T29
The transcription factor Ikaros represses Notch signaling. Since Ikaros and Notch treanscriptional mediator RBPJ both recognize sequences that contain the same core TGGGAA motif, it was hypothesized that Ikaros represses Notch signaling by targeting Notch response elements and competing with RBPJ fo...
ORGANISM(S): Mus musculus 
2014-04-02 | E-GEOD-46119 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of T cell fraction enriched for donor antigen-reactive T cells in skin allografted recipient mice (II)
Measurement of specific gene expression in clinical samples is a promising approach for monitoring the recipient immune status to the graft in organ transplantation. Identification of biomarker genes closely associated with tolerance or rejection is critical for this monitoring protocol. Unlike prev...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-32953 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of T cell fraction enriched for donor antigen-reactive T cells in skin allografted recipient mice (I)
Measurement of specific gene expression in clinical samples is a promising approach for monitoring the recipient immune status to the graft in organ transplantation. Identification of biomarker genes closely associated with tolerance or rejection is critical for this monitoring protocol. Unlike prev...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-32952 | biostudies-arrayexpress
TranscriptomicsCharacterization of A Novel CRAC Inhibitor that Potently Blocks Human T cell Activation and Effector Functions
Store operated calcium entry (SOCE) downstream of T cell receptor (TCR) activation in T lymphocytes has been shown to be mediated mainly through the Calcium Release Activated Calcium (CRAC) channel. Here, we compared the effects of a novel, potent and selective CRAC inhibitor, 2,6-Difluoro-N-{5-[4-m...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43210 | biostudies-arrayexpress
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