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MetabolomicsExtreme genome diversity and cryptic speciation in a harmful algal bloom forming eukaryote

Harmful algal blooms (HABs) of the toxic haptophyte Prymnesium parvum are a recurrent problem in many inland and estuarine waters around the world. Strains of P. parvum vary in the toxins they produce and in other physiological traits associated with HABs, but the genetic basis ...

2023-04-26 | MTBLS5893 | MetaboLights
TranscriptomicsGene expression profiling of in vitro derived induced and natural FOXP3+ regulatory T cells and ex-iTreg cells in the mouse
Induced Treg (iTreg) cells are essential for tolerance and can be used therapeutically, yet their stability in vivo and mechanisms of suppression are unresolved. Here, we used a treatment model of colitis to examine the role of autologous IL-10 in iTreg cell function. Mice treated with IL-10+/+ iTr...
ORGANISM(S): Mus musculus 
2012-12-06 | E-GEOD-35543 | biostudies-arrayexpress
ProteomicsAlterations of Ceramide Synthesis Induce PD-L1 Internalization and Signaling to Regulate Tumor Metastasis and Immunotherapy Response
Programmed death-ligand 1, PD-L1 (CD274) facilitates immune evasion and exerts pro-survival functions in cancer cells. Here, we report a new mechanism whereby internalization of PD-L1 in response to alterations of bioactive lipid/ceramide metabolism by ceramide synthase 4 (CerS4) induces sonic-hedge...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD053108 | Pride
Sonic-hedgehog Ceramide Sphingolipid Cers4 Pd-l1 Metastasis Immunotherapy 
UnknownCharacteristics of Adults With Diagnosed HIV Who Experienced Housing Instability: Findings From the Centers for Disease Control and Prevention Medical Monitoring Project, United States, 2018.
Not available
S-EPMC9124455 | biostudies-literature
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