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ProteomicsProteomic study of the effect of Callyaerin B derivativs on M. tuberculosis H37Rv
The natural cyclopeptide Callyaerin B (CalB) exhibits highly specific antitubercular activity. The aim of this project is to study the proteome dysregulation induced by CalB treatment of M. tuberculosis H37Rv wild type cells using a whole proteome comparison approach. In addition, it has been shown,...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2024-07-25 | PXD050763 | Pride
M. tuberculosis h37rv  callyaerin b  cal b 
ProteomicsLFQ proteomics analysis of M. smegmatis treated with BacPROTACs.
To monitor selective degradation of ClpC1 and ClpC2 using BacPROTAC compounds in M. smegmatis we performed a LFQ proteomics analysis treating the cells at bactericidal compound concentration. We detected degradation of both proteins and additional dysregulation of the mycobacterial PQC system.
ORGANISM(S): Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
2023-06-07 | PXD037235 | Pride
Antibiotics Tpd Bacprotac Protac Protein degradation 
UnknownAchieving Kaiser Permanente quality.
Not available
S-EPMC4892964 | biostudies-literature
MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
Unknownm.3685T > C is a novel mitochondrial DNA variant that causes Leigh syndrome.
Not available
S-EPMC8958915 | biostudies-literature
ProteomicsAffinity-based protein profiling (AfBPP) using different Callyaerin probes in M. tuberculosis H37Rv
The natural cyclopeptide Callyaerin B (CalB) exhibits highly specific antitubercular activity. The aim of this project is to study the protein binding partner of this compound using either activity-based protein profiling (ABPP) (ACE_0721) or affinity-based protein profiling (AfBPP) (ACE_0682 & ACE_...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2024-07-25 | PXD050770 | Pride
Callyaerin  mycobacterium tuberculosis  cyclopeptide  natural product  antibiotic action  anti-tb drug development  photoaffinity labelling 
UnknownPhysical Performance and Cognition in a Diverse Cohort: Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study.
Not available
S-EPMC7904590 | biostudies-literature
TranscriptomicsBreast tumor DNA methylation
Using primary breast tumors from 162 women from the Kaiser Division of Research Pathways Study and the Illumina GoldenGate methylation bead-array platform, we measured CpG loci associated with cancer-related genes 162 tumor specimens from the initial diagnostic biopsy were obtained from the KPNC tum...
ORGANISM(S): Homo sapiens 
2010-07-28 | E-GEOD-22290 | biostudies-arrayexpress
UnknownA retrospective analysis of health systems in Denmark and Kaiser Permanente.
Not available
S-EPMC2630928 | biostudies-literature
TranscriptomicsClassification of Myeloma Using Global MicroRNA Profiling
Myeloma is a heterogeneous disease. In this work we used global microRNA profiling to classify clinical samples from UK MRC Myeloma IX, and developed a microRNA-based M-bM-^@M-^\outcome classifierM-bM-^@M-^] for risk stratification. Global microRNA expression profiling was carried out in 163 newly d...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-41276 | biostudies-arrayexpress
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