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ProteomicsThe expression of the acarbose biosynthetic gene cluster of Actinoplanes sp. SE50/110 is dependent on the growth phase
Actinoplanes sp. SE50/110 produces the diabetes type II drug acarbose only during the growth phase and not in the stationary phase. This correlation between the course of the cell growth and the biosynthesis could be due to a decreasing expression of the acarbose biosynthesis genes until the station...
ORGANISM(S): Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110) 
2021-09-09 | PXD017973 | Pride
Acarbose Proteomics Co-regulation Transcriptomics Actinoplanes sp. se50/110 Expression dynamics 
ProteomicsMulti-omics analysis of mutagenized S. rimosus reveals synergistic changes that drive oxytetracycline production towards industrial efficiency and opens a new route to heterologous polyketides
The present work provides a multi-omics systems-wide view on S. rimosus. Using genomics, transcriptomics, proteomics, and metabolomics, we compared the wild type with an OTC-overproducing derivative, previously obtained by classical mutagenesis. The integration of the data provided a deep insight in...
ORGANISM(S): Streptomyces rimosus subsp. rimosus 
2024-01-26 | PXD042182 | Pride
Streptomyces rimosus Lc-msms Rnaseq 
UnknownA maltose-regulated large genomic region is activated by the transcriptional regulator MalT in Actinoplanes sp. SE50/110.
Not available
S-EPMC7567727 | biostudies-literature
UnknownTranscriptome sequencing of the human pathogen Corynebacterium diphtheriae NCTC 13129 provides detailed insights into its transcriptional landscape and into DtxR-mediated transcriptional regulation.
Not available
S-EPMC5784534 | biostudies-literature
UnknownAbsence of the highly expressed small carbohydrate-binding protein Cgt improves the acarbose formation in Actinoplanes sp. SE50/110.
Not available
S-EPMC7275007 | biostudies-literature
UnknownEvaluation of vector systems and promoters for overexpression of the acarbose biosynthesis gene acbC in Actinoplanes sp. SE50/110.
Not available
S-EPMC6599336 | biostudies-literature
UnknownDeciphering the Adaptation of Corynebacterium glutamicum in Transition from Aerobiosis via Microaerobiosis to Anaerobiosis.
Not available
S-EPMC6027265 | biostudies-literature
UnknownIsolation and genome sequencing of four Arctic marine Psychrobacter strains exhibiting multicopper oxidase activity.
Not available
S-EPMC4754876 | biostudies-literature
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