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ProteomicsTranslational and Post-translational LC-MS of Naïve and Primed hESCs
Deciphering the regulatory network for human naïve and primed pluripotency is of fundamental theoretical and applicable significance. Here, by combining quantitative proteomics, phosphoproteomics and acetylproteomics analyses, we revealed RNA processing and translation as the most differentially-reg...
ORGANISM(S): Homo sapiens (Human) 
2021-12-10 | PXD030230 | Pride
Lc-ms Primed Human Hesc Naïve 
ProteomicsComparative phosphoproteomic analyses of OCT4 protein in hESC
This study is directed to systematically map out phosphorylation sites in OCT4 protein that are differentially phosphorylated between naïve hESCs and their primed counterparts, and to further identify the upstream kinases that phosphorylate the sites in naïve hESC-specific manner
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD033619 | Pride
Human Lc-ms/ms Hesc 
ProteomicsEndogenous OCT4 interactome in hESC
In two widely-cited OCT4-protein interactome papers, Ding et al. (Ding et al., 2012) used murine ESC nuclear extract to identify OCT4 interactome in nucleus and Pardo et al. (Pardo et al., 2010) used whole cell lysate to identify OCT4 interactome in murine ESCs. In both papers, Benzonase, a genetica...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD033840 | Pride
Oct4 Esc Human 
ProteomicsExploration of the antioxidant effect of spermidine on the ovary and screening and identification of differentially expressed proteins
Spermidine is a naturally occurring polyamine compound that has many biological functions, such as inducing autophagy and anti-inflammatory and anti-aging effects. In this study, ICR mice were fed exogenous spermidine drinking water for three months to explore the regulation of ovarian function by s...
ORGANISM(S): Mus Musculus 
2022-12-12 | PXD038755 |
UnknownThe Complete Chloroplast Genome of the Hare's Ear Root, Bupleurum falcatum: Its Molecular Features.
Not available
S-EPMC4880840 | biostudies-literature
MetabolomicsCreatine uptake promotes dendritic cell activation and enhances antitumor immunity

Dendritic cells (DCs) are central regulators of antitumor T cell immunity and are highly sensitive to metabolic cues. However, the therapeutic potential of targeting DC metabolism remains underexplored. Here, we report upregulation of the creatine transporter (CrT; Slc6a8) in intratumora...

2026-03-11 | MTBLS12797 | MetaboLights
UnknownAssessment on the Fermentation Quality and Bacterial Community of Mixed Silage of Faba Bean With Forage Wheat or Oat.
Not available
S-EPMC9114351 | biostudies-literature
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Untargeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7840 | MetaboLights
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Targeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7832 | MetaboLights
UnknownThe complete chloroplast genome sequence of medicinal plant, Artemisia argyi.
Not available
S-EPMC7799501 | biostudies-literature
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