Sort   by:  
 Page size 
TranscriptomicsThe Histone H2B Monoubiquitination Regulatory Pathway is Required for Differentiation of Multipotent Stem Cells
Extensive changes in post-translational histone modifications accompany the rewiring of the transcriptional program during stem cell differentiation. However, the mechanisms controlling the changes in specific chromatin modifications and their function during differentiation remain only poorly under...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-38173 | biostudies-arrayexpress
ProteomicsUSP9X phosphopeptide mapping - We previously identified the deubiquitylase USP9X as a G2/M-specific CDC14B interactor (PXD012732). The functional connection of these proteins has been further investigated by a quantitative comparison of USP9X phosphorylation in WT vs CDC14B-overexpressing HEK 293Tcells (ATCC® CRL-3216™). The approach identified USP9X serine 2563 as a specific CDC14B target. Phosphorylation at USP9XS2563 has been confirmed by in-house phosphospecific antibodies.
We previously identified the deubiquitylase USP9X as a G2/M-specific CDC14B interactor (PXD012732). The functional connection of these proteins has been further investigated by a quantitative comparison of USP9X phosphorylation in WT vs CDC14B-overexpressing HEK 293Tcells (ATCC® CRL-3216™). The appr...
ORGANISM(S): Homo sapiens (Human) 
2020-03-25 | PXD012733 | Pride
Cdc14b Usp9x 
UnknownMOF maintains transcriptional programs regulating cellular stress response.
Not available
S-EPMC4893634 | biostudies-literature
UnknownSIRT2 directs the replication stress response through CDK9 deacetylation.
Not available
S-EPMC3746840 | biostudies-literature
UnknownMDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.
Not available
S-EPMC6284523 | biostudies-literature
TranscriptomicsAnalysis of MOF under stress conditions
We analyzed the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin. Mof was deleted in MEFs using the Cre-ERT2 trasgene, while Mof was knockdown in podocytes using shRNA infection. Samples were treated with Adriamycin for 24 hours and gene expression changes analysed....
ORGANISM(S): Mus musculus 
2015-07-10 | E-GEOD-70706 | biostudies-arrayexpress
UnknownThe OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma.
Not available
S-EPMC9574752 | biostudies-literature
ProteomicsCDC14B interactome - The proteomic approach aimed at the identification of interaction partners for the human dual phosphatase and tumor suppressor CDC14B by Co-inmunoprecipitation (Co-IP) experiments. In this approach, CDC14B interactomes from unsynchronized and G2/M enriched cells were compared semi-quantitatively based on spectral counting. This approach yielded the deubiquitylase USP9X as a G2/M-specific CDC14B interactor which has been confirmed by Western-blot (WB).
The proteomic approach aimed at the identification of interaction partners for the human dual phosphatase and tumor suppressor CDC14B by Co-inmunoprecipitation (Co-IP) experiments. In this approach, CDC14B interactomes from unsynchronized and G2/M enriched cells were compared semi-quantitatively bas...
ORGANISM(S): Homo sapiens (Human) 
2020-03-25 | PXD012732 | Pride
Usp9x Cdc14b 
ProteomicsThe OTUD6B-LIN28B-MYC axis determines cell cycle progression in multiple myeloma
Deubiquitylases (DUBs) remove ubiquitin from proteins. In the context of cancer, their inhibition can induce the degradation of oncoproteins, that may otherwise be “undruggable”. Multiple myeloma (MM) is the second most common hematological malignancy with poor outcome and high sensitivity towards u...
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD027480 | Pride
Bioid Human Flag-ip Orbitrap Otud6b 
ProteomicsIdentification of mitotic substrates of phospho-regulated USP9X
We previously identified the deubiquitylase USP9X as a G2/M-specific CDC14B interactor (PXD012732) and subsequently identified USP9X as a specific CDC14B target (PXD012733). To investigate relevant mitotic substrates of phospho-regulated USP9X, we next performed a Stable isotope labeling by amino ac...
ORGANISM(S): Homo sapiens (Human) 
2020-03-25 | PXD012734 | Pride
Usp9x Ubiquitinylation 
Sort   by:  
 Page size