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ProteomicsTargeting Ubiquitin Signaling vulnerabilities in KEAP1-Inactivated Lung Cancer
Lung cancer cells rely on protein homeostasis regulators, especially within the ubiquitin-proteasome system (UPS), to sustain malignancy. Genetic alterations in UPS components, such as E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs), are common and create context-dependent therapeutic...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-04 | PXD067472 | Pride
Mouse Kp Lung Kpl Kpp 
ProteomicsEngineering CRBN for high throughput screening and molecular glue discovery
The majority of clinical degraders utilize an immunomodulatory imide drug (IMiD)-based derivative, that directs their target to the E3 ligase receptor Cereblon (CRBN), however, identification of new IMiD molecular glue substrates has remained underexplored. To tackle this, we design human CRBN const...
ORGANISM(S): Homo sapiens (Human) 
2024-12-06 | PXD056863 | Pride
Coip Flagcrbn Wcp 
ProteomicsBiofilm responsive proteins of Candida albicans ATCC10231
Present study represents the peptide mass data of proteins expressed during biofilm form growth of Candida albicans ATCC10231.
ORGANISM(S): Candida Albicans Atcc10231 
2023-01-06 | MSV000091018 | MassIVE
ProteomicsProteomic data of opaque form responsive proteins of Candida albicans ATCC10231
Data represents the raw proteomic data generated by SWATH-MS analysis of Candida albicans (ATCC 10231) opaque form cells.
ORGANISM(S): Candida Albicans Atcc10231 
2022-12-31 | MSV000090980 | MassIVE
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