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MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
UnknownProtective and Pathogenic Roles of CD8+ T Lymphocytes in Murine Orientia tsutsugamushi Infection.
Not available
S-EPMC5015871 | biostudies-literature
UnknownDissemination of Orientia tsutsugamushi and inflammatory responses in a murine model of scrub typhus.
Not available
S-EPMC4133189 | biostudies-literature
UnknownCCR2 Deficiency Impairs Ly6Clo and Ly6Chi Monocyte Responses in Orientia tsutsugamushi Infection.
Not available
S-EPMC8287586 | biostudies-literature
UnknownGFPuv-Expressing Recombinant Rickettsia typhi: a Useful Tool for the Study of Pathogenesis and CD8+ T Cell Immunology in R. typhi Infection.
Not available
S-EPMC5442613 | biostudies-literature
UnknownOrientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo.
Not available
S-EPMC5913972 | biostudies-literature
ProteomicsThe IMiD receptor CRBN determines quality control of transmembrane proteins
The complex architecture of transmembrane proteins requires quality control (QC) for folding and membrane positioning, a prerequisite for cellular homoeostasis and intercellular communication. However, it has remained unclear whether transmembrane proteins-specific QC hubs exist. Here we specify Cer...
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD018244 | Pride
Imids Chaperones Membrane proteins Lumos Human Multiple myeloma 
ProteomicsElectroneutral polymer nanodiscs enable interference-free probing of membrane proteins in a lipid-bilayer environment
Membrane proteins can be examined in near-native lipid-bilayer environments with the advent of polymer-encapsulated nanodiscs. These nanodiscs self-assemble directly from cellular membranes, allowing in vitro probing of membrane proteins with techniques that had previously been restricted to soluble...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD030958 | Pride
Membrane proteins Dibma nanodiscs 
UnknownRift Valley fever virus detection in susceptible hosts with special emphasis in insects.
Not available
S-EPMC8110843 | biostudies-literature
ProteomicsThe OTUD6B-LIN28B-MYC axis determines cell cycle progression in multiple myeloma
Deubiquitylases (DUBs) remove ubiquitin from proteins. In the context of cancer, their inhibition can induce the degradation of oncoproteins, that may otherwise be “undruggable”. Multiple myeloma (MM) is the second most common hematological malignancy with poor outcome and high sensitivity towards u...
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD027480 | Pride
Bioid Human Flag-ip Orbitrap Otud6b 
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