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ProteomicsEssential role of translation factor eIF5a in cytokine and cell cycle regulation in primary mouse CD8 T lymphocyte
Translation of specific mRNAs is tightly regulated in primary T cells to ensure correct timing and precise delivery of protein syntheses in response to environmental cues. Translation factor eIF5a is known to be important for protein synthesis and is expected to regulate translation of certain diffi...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-11 | PXD021063 | Pride
Cytokine Lymphocyte Hypusine Proliferation Eif5a 
TranscriptomicsNeuroblastoma cell lines
Untreated neuroblastoma cell lines SMS-KCN, SMS-KCNR, Kelly, and SH-SY5Y were sequenced on an Illumina GA IIx sequencer.
ORGANISM(S): Homo sapiens 
2014-12-30 | E-MTAB-2690 | biostudies-arrayexpress
UnknownEvaluation of tissue-engineered human acellular vessels as a Blalock-Taussig-Thomas shunt in a juvenile primate model.
Not available
S-EPMC10556952 | biostudies-literature
ProteomicsIn-depth mass spectrometry-based proteomics of formalin-fixed, paraffin embedded tissues with a spatial resolution of 50–200 µm
Formalin-fixed, paraffin-embedded (FFPE) tissues are banked in large repositories as a cost-effective means of preserving invaluable specimens for subsequent study, including for clinical proteomics in translational medicine. With the rapid growth of spatial proteomics, FFPE tissue samples can serve...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-02 | PXD029729 | Pride
Fresh frozen Spatial Ddm Ffpe Lcm 
TranscriptomicsTranscription profiling of human T-ALL cell cultures treated with Compound E, a gamma-secretase inhibitor or vehicle only (DMSO) for 24 h
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a critical role during T-cell development and in the pathogenesis over 50% of human T-cell lymphoblastic leukemia (T-ALL) cases. However, little is known about the transcrip...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5827 | biostudies-arrayexpress
Metabolomicsmetabolomics Analysis in Cecal Samples
Targeted LC/MS Metabolomics. Cecal contents were lyophilized overnight and approximately 2.5-5 mg was homogenized in 250 µL of 50% acidified acetonitrile (0.3% formic acid) for targeted LC/MS/MS metabolomics (acylcarnitines, amino acids, organic acids, nucleotides, and CoAs) according to validated, ...
2026-06-19 | MTBLS14783 | MetaboLights
UnknownBispecific PSMA antibodies and CAR-T in metastatic castration-resistant prostate cancer.
Not available
S-EPMC10285603 | biostudies-literature
TranscriptomicsChromatin immunoprecipitation of REST/NRSF
ENCODE ChIP-chip study using 8 diverse human cell lines; 4 of neural origin (NB69, KELLY, SHSY-5Y, U373) and 4 of non-neural origin (HeLa, HepG2, HEK293 and K562) and anti-REST/NRSF antibody (Santa Cruz Biotech; sc-25398 aka H290) to asses REST-genome interactions across 1% of the human genome used...
ORGANISM(S): Homo sapiens 
2009-03-31 | E-TABM-660 | biostudies-arrayexpress
ProteomicsFully automated sample processing and analysis workflow for low-input proteome profiling
Recent advances in sample preparation and analysis have enabled direct profiling of protein expression in single mammalian cells and other trace samples for characterization of cellular heterogeneity and high-resolution mapping of tissues. Several techniques used to prepare and analyze low-input sam...
ORGANISM(S): Homo sapiens (Human) 
2020-12-21 | PXD021882 | Pride
Low-input sample preparation Low-input proteomics 
UnknownBispecific T-Cell Engagers Therapies in Solid Tumors: Focusing on Prostate Cancer.
Not available
S-EPMC10001031 | biostudies-literature
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