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TranscriptomicsMassively parallel single-cell RNA-Seq for dissecting cell type and cell state compositions
In multi-cellular organisms, biological function emerges when cells of heterogeneous types and states are combined into complex tissues. Nevertheless unbiased dissection of tissues into coherent cell subpopulations is currently lacking. We introduce an automated, massively parallel single cell RNA s...
ORGANISM(S): Mus musculus 
2014-02-14 | E-GEOD-54006 | biostudies-arrayexpress
TranscriptomicsTissue-resident macrophage enhancer landscapes are shaped by the local microenvironment [RNA-seq]
Macrophages are hematopoietic cells critical for innate immune defense, but also control organ homeostasis in a tissue-specific manner. Tissue-resident macrophages, therefore, provide a well-defined model to study the impact of ontogeny and microenvironment on chromatin state. Here, we profile the d...
ORGANISM(S): Mus musculus 
2014-12-05 | E-GEOD-63340 | biostudies-arrayexpress
TranscriptomicsRNA-Seq global gene expression in lung tissue at ten time points during a 7-day time course of infection
Hundreds of immune cell types work in coordination to maintain tissue homeostasis. Upon infection, dramatic changes occur with the localization, migration and proliferation of the immune cells to first alert the body of the danger, confine it to limit spreading, and finally extinguish the threat and...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-49933 | biostudies-arrayexpress
GenomicsChromatin state dynamics during blood formation (ChIP-Seq)
We develop a new ChIpseq method (iChIP) to profile chromatin states of low cell number samples. We use IChIP to profile the chromatin dynamics during hematopoiesis across 16 different cell types which include the principal hematopoietic progenitors Examination of 2 different histone modifications in...
ORGANISM(S): Mus musculus 
2014-08-08 | E-GEOD-59636 | biostudies-arrayexpress
TranscriptomicsRNA-Seq global gene expression of four Dendritic cells subpopulations from lung (CD8+ and CD8- pDCs, CD103-CD11b+ and CD103+CD11b- cDCs) of influenza infected mice at four time points following infection
Hundreds of immune cell types work in coordination to maintain tissue homeostasis. Upon infection, dramatic changes occur with the localization, migration and proliferation of the immune cells to first alert the body of the danger, confine it to limit spreading, and finally extinguish the threat and...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-49932 | biostudies-arrayexpress
UnknownBiased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene.
Not available
S-EPMC2231382 | biostudies-literature
UnknownChronic exposure to TGFβ1 regulates myeloid cell inflammatory response in an IRF7-dependent manner.
Not available
S-EPMC4282639 | biostudies-literature
UnknownTissue-resident macrophage enhancer landscapes are shaped by the local microenvironment.
Not available
S-EPMC4437213 | biostudies-literature
UnknownPD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model.
Not available
S-EPMC6349941 | biostudies-literature
UnknownMassively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types.
Not available
S-EPMC4412462 | biostudies-literature
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