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ProteomicsHEK293T MS - Representing dynamic biological networks with multi-scale probabilistic models
As an example of a comprehensive model of signal transduction, we provide a Wnt network that shows remarkable robustness under a range of phenotypical and pathological conditions. Its simulation allows the clarification of controversially discussed molecular mechanisms of Wnt signalling by predictin...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011835 | Pride
Human Rac1 St-rna knockdown Hek293t Jnk2 Jnk1 
ModelsAurora Kinase A in Neuroblastoma
Aurora Kinase A (AURKA) is often overexpressed in neuroblastoma (NB) with poor outcome. The causes of AURKA overexpression in NB are unknown. Here, we describe a gene regulatory network consisting of core regulators of AURKA protein expression and activation during mitosis to identify potential caus...
7916 | Cell Collective
TranscriptomicsSite-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response
Physiologically, Notch signal transduction plays a pivotal role in differentiation; pathologically, Notch signaling contributes to the development of cancer. Transcriptional activation of Notch target genes involves cleavage of the Notch receptor in response to ligand binding, production of the Notc...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-62528 | biostudies-arrayexpress
Transcriptomicsp53 deletion induces liver carcinoma with bilineal differentiation
Background and Aims: p53 can limit the self-renewal of stem cells from various tissues. Experimental evidence suggests that deletion of p53 can cooperate with other oncogenic events to induce aberrant self-renewal and transformation of progenitor cells. It is not known whether p53 deletion alone can...
ORGANISM(S): Mus musculus 
2011-12-29 | E-GEOD-34760 | biostudies-arrayexpress
UnknownGenetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive.
Not available
S-EPMC5078585 | biostudies-literature
ModelsCardiac development
Two types of distinct cardiac progenitor cell populations can be identified during early heart development: the first heart field (FHF) and second heart field (SHF) lineage that later form the mature heart. They can be characterized by differential expression of transcription and signaling factors. ...
2136 | Cell Collective
ModelsPredicting Variabilities in Cardiac Gene
Gene interactions in cells can be represented by gene regulatory networks. A Boolean network models gene interactions according to rules where gene expression is represented by binary values (on / off or {1, 0}). In reality, however, the genes state can have multiple values due to biological propert...
4706 | Cell Collective
ModelsSenescence Associated Secretory Phenotype
Cells and tissues are exposed to stress from numerous sources. Senescence is a protective mechanism that prevents malignant tissue changes and constitutes a fundamental mechanism of aging. It can be accompanied by a senescence associated secretory phenotype (SASP) that causes chronic inflammation. W...
11863 | Cell Collective
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