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ProteomicsProteogenomic Identification and Validation of Key Differentially Expressed Molecular Targets for Keloid Disease
The study incorporated 5 keloid disease (KD) and 5 normal skin (NS) samples, and due to challenges in obtaining primary samples, we had a sample size of 3 biological replicates for FKN, 3 for DFSP made up of 2 primary cells and 1 cell line, and 2 Fibrosarcoma cell lines FS-CL-1 (HT-1080 [HT1080], C...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-29 | MSV000091168 | MassIVE
ProteomicsTMT-based proteomics analysis identifies RPLP1 as a key protein target in ursolic acid inhibition of colorectal cancer
Purpose: Ursolic Acid (UA), a triterpenoid extracted from Hedyotis Diffusa Willd. (HDW), is known for its anti-inflammatory, antioxidant, and antitumor effects. Nevertheless, the mechanisms underlying UA's anti-colorectal cancer (CRC) effects remain insufficiently understood. This study is aim to id...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD063684 | Pride
Colorectal cancer  hedyotis diffusa willd  ursolic acid  rplp1  tandem mass tags 
ProteomicsDisturbance of key cellular subproteomes upon propofol treatment is associated with increased permeability of the blood-brain barrier
Background: Propofol is a short-acting anesthetic, which is often used for induction and maintenance of general anesthesia, sedation for mechanically ventilated adults and procedural sedation. Several side effects of propofol are known and a substantial number of patients suffer from post-operative ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD033856 | Pride
Anesthetics  blood-brain barrier  dna damage response  drug effect  human brain microvascular endothelial cells  metabolic stress  propofol  proteome  quantitative proteomics  reactive oxygen species (ros) 
Proteomicsrat neutrophils phosphoproteome analysis
Intestinal ischemia reperfusion injury (iIRI) is a severe clinical condition presenting high morbidity and mortality worldwide. Some of the systemic consequences of iIRI can be prevented by applying ischemic preconditioning (iIPC), a series of short ischemia/reperfusion events preceding the major is...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2019-11-06 | MSV000084545 | MassIVE
ProteomicsIdentification of key regulatory pathways in response to long-term zinc supplementation in human primary retinal pigment epithelium: a multi-omics approachIdentification of key regulatory pathways in response to long-term zinc supplementation in human primary retinal pigment epithelium: a multi-omics approach
In age-related macular degeneration (AMD), both systemic and local zinc concentrations are decreased. Elevating zinc levels by nutrition or oral supplementation has a positive impact on delaying the progression to end-stage AMD in clinical studies. Here we set out to identify key regulatory pathways...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020860 | Pride
Multi-omics approach Age-related macular degeneration Retinal pigment epithelium Zinc 
ProteomicsIntegrated proteomics and phosphoproteomics analyses reveal the broad and complex influence by inhibition of L-type amino acid transporter-1 in biliary tract carcinoma cells
To characterize the changes of phosphorylation signaling cascades and protein expressions induced by LAT1 inhibition in 4 cell lines of biliary tract cancer treated with LAT1 specific inhibitor JPH203, immobilized metal affinity chromatography and liquid chromatography-tandem mass spectrometry with ...
ORGANISM(S): Homo Sapiens (human) 
2020-12-25 | PXD019458 | JPOST Repository
ProteomicsStress-Induced Premature Senescence in High Five Cell Cultures: A Principal Factor in Cell-Density Effects
The Baculovirus Expression Vector System (BEVS) is highly valued in vaccine development, protein engineering, and drug metabolism research due to its biosafety, operational convenience, rapid scalability, and capacity for self-assembling virus-like particles. However, increasing cell density at the ...
ORGANISM(S): Trichoplusia Ni 
2024-10-31 | PXD057379 |
ProteomicsQuantitative proteomics characterization on the effect and mechanism of trichostatin A on hippocampus of type II diabetic mice
Cognitive dysfunction is the main feature of diabetic encephalopathy (DE). The effect and mechanism of trichostatin A (TSA) on cognitive function of diabetic mice is not elucidated. Our study revealed the key pathways and vital hubgenes of the effect of TSA on hippocampus of type II diabetic mice, i...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD036588 | Pride
Proteomics Diabetic encephalopathy Cognitive function Drug screening Trichostatin a 
ProteomicsUnveiling the Key Role of GPX3 in Oxidative Stress and Tumor Metastasis in Gallbladder Cancer: A Comprehensive Study from Cellular to In Vivo Investigations
This study aimed to explore the effect of GPx3 expression changes in gallbladder cancer on oxidative stress and glycolysis, as well as its key role in immune escape and metastasis of gallbladder cancer.
ORGANISM(S): Homo Sapiens 
2025-03-04 | PXD061486 |
ProteomicsM.musculus - Suprachiasmatic nucleus, iBAQ (Chiangetal,plosgenetics.2014)
abundance based on iBAQ, Interaction consistency score: 15.5, Coverage: 18
ORGANISM(S): 10090 
2014-00-00 | 1300563876 | PAXDB
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