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MetabolomicsLipidomic analysis of Drosophila on different sugar feeding regimes +/- trametinib

Consumption of sugar-rich diets adversely affects health and reduces life expectancy through the excessive production and storage of triacylglycerides (TAGs) leading to metabolic dysfunction. Here, using Drosophila melanogaster, we identify the conserved Ras/MAPK signalling pathway as a key media...

2026-09-02 | MTBLS14468 | MetaboLights
TranscriptomicsKRAS-Dependent Sorting of miRNAs and other small RNAs to secreted vesicles
Although long thought to act cell autonomously, mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. We have previously shown that mutant KRAS induces EGFR-ligand trafficking to exosomes and drastically alters exosomal protein contents,...
ORGANISM(S): Homo sapiens 
2015-08-28 | E-GEOD-67004 | biostudies-arrayexpress
TranscriptomicsEffects of physiological and synthetic IAP antagonism on c-IAP dependent signaling
Cellular inhibitor of apoptosis proteins 1 and 2 (c-IAP1/2) play central roles in signal transduction mediated by numerous receptors that participate in inflammatory and immune responses. In certain pathways, such as activation of NF-kB, their degradation is a major regulatory event and is physiolog...
ORGANISM(S): Homo sapiens 
2015-02-09 | E-GEOD-64927 | biostudies-arrayexpress
TranscriptomicsRegulatory and effector T cells in Lymphocytic choriomeningitis virus WE infection
In this study, we determined the signature of CD4+Foxp3- effector T cells and CD4+Foxp3+ Treg cells in naive animals and following LCMV WE infection. In addition, transcriptional signatures were determined in CXCR3+ CD4+Foxp3+ Treg cells arising in Th1 settings following LCMV infection.
ORGANISM(S): Mus musculus 
2020-03-11 | E-MTAB-8861 | biostudies-arrayexpress
TranscriptomicsMethylation profiling by array of human and TC1 and TC0 mouse strain livers and testes to study human repetitive elements on human chromosome 21 in a heterologous mouse environment
The aim of this project is to study human repetitive elements on human chromosome 21 in a heterologous mouse environment (Tc1 mouse). To determine the unbiased regulation of the human genome, suppressed regions of human chromosome 21 were identified in vivo in liver and testes of human and Tc1 mouse...
ORGANISM(S): Mus musculus 
2012-12-13 | E-MTAB-1304 | biostudies-arrayexpress
Transcriptomicssingle-cell RNA sequencing of effector memory CD8+ T cells of nasal-associated lymphoid tissue (NALT), spleen, submandibular & cervical lymph nodes and blood of Epstein Barr Virus (EBV)-infected NSG mice engrafted with a human immune system (HIS mice)
To identify the difference in transcriptome of effector memory CD8+ T cells in different tissues of EBV-infected HIS mice, we sorted CD8+ CD62L- CD45RA- cells from NALT, spleen, lymph node and blood via flow cytometry-assisted sorting. We pooled the cells of three individual mice together in equal c...
ORGANISM(S): Homo sapiens 
2024-08-31 | E-MTAB-13853 | biostudies-arrayexpress
ProteomicsMudPIT analyses of the proteins co-purified with components of the LSD1 (KDM1A) transcriptional repressor complex and the non-canonical BAF complex, immuno-precipitated from MKL-1 and WaGa MCC cell lines
Protein Complexes Purification: Immunoprecipitations were performed with antibodies to LSD1 (2139; Cell signaling technology), INSM1 Mouse (SC-271408, Santa Cruz Biotechnology), RCOR2 (23969-1-AP; Proteintech Group), BRD9 (61537; Active Motif Rabbit), and normal Rabbit IgG (2729; Cell signaling tech...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-01-25 | MSV000083364 | MassIVE
TranscriptomicsInterplay of host microbiota, genetic perturbations, and inflammation promote local development of intestinal neoplasms in mice
The preferential localization of some neoplasms, such as serrated polyps, in specific areas of the intestine suggests that non-genetic factors may be important for their development. To test this hypothesis, we took advantage of transgenic mice that expressed HB-EGF throughout the intestine, but dev...
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-47735 | biostudies-arrayexpress
TranscriptomicsSessile serrated adenomas and conventional adenomas of the colon
Sessile serrated adenomas are now recognized as precursor lesions of a substantial subset of colorectal cancers arising via a so-called “serrated pathway”. However, their biological markers remain to be defined. The aim of our study was to identify differentially expressed genes in sessile serrated ...
ORGANISM(S): Homo sapiens 
2008-08-26 | E-GEOD-12514 | biostudies-arrayexpress
TranscriptomicsAlteration of microRNA gene expression by EBV encoded LMP1 oncogene
The Epstein Barr virus (EBV) encoded latent membrane protein-1 (LMP1) is a functional homologue of the tumor necrosis factor receptor family and contributes substantially to the oncogenic potential of EBV through activation of Nuclear Factor-kappaB (NF-kappaB). MicroRNAs (miRNAs) are a class of smal...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10105 | biostudies-arrayexpress
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