Sort   by:  
 Page size 
ProteomicsThe PDE4 inhibitor apremilast modulates ethanol responses in Gabrb1 S409A knock-in mice via PKA-dependent and independent mechanisms
We previously showed that the PDE4 inhibitor apremilast reduces ethanol consumption in mice by protein kinase A (PKA) and GABAergic mechanisms. Preventing PKA phosphorylation of GABAA 3 subunits partially blocked apremilast-mediated decreases in alcohol drinking. Here, we produced Gabrb1-S409A knock...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-06 | PXD052839 | Pride
Gaba a receptor Mutany Apremilast Pka Gabrb1 Ethanol 
ProteomicsStudying the role of LMTK3 in the brain
Studying the phosphorylation events related to LMTK3 and its associated proteins in the brain. LMTK3 appears to be associated with the excitatory and inhibitory synaptic machinery, therefore this study was carried out to examine it's role in modulating inhibitory synapses.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-05-22 | PXD050212 | Pride
Synapse Phosphorylation Gaba Mouse Lmtk3 Brain 
MetabolomicsMetabolomic Responses of Arabidopsis Suspension Cells to Bicarbonate under Light and Dark Conditions
Global CO2 level presently recorded at 400 ppm is expected to reach 550 ppm in 2050, an increment likely to impact plant growth and productivity. Using targeted LC-MS and GC-MS platforms we quantified 229 and 29 metabolites, respectively in a time-course study to reveal short-term responses to diffe...
2017-04-25 | MTBLS311 | MetaboLights
UnknownClinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Not available
S-EPMC6366813 | biostudies-literature
ProteomicsIsolation and characterization of multi-protein complexes enriched in the K-Cl co-transporter 2 from brain plasma membranes
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanism neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address these issues, we used affinity purification to isolate stable multi-protein complexes of...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021368 | Pride
Kcc2 Phosphorylation Proteome Interactome 
UnknownTargeted Incentive Programs For Lung Cancer Screening Can Improve Population Health And Economic Efficiency.
Not available
S-EPMC6409129 | biostudies-literature
no omics definedSingle cell RNA sequencing mapping the adult human esophagus in vivo and in vitro
Despite advances and innovations in characterization of adult esophageal epithelial stem cells, there is still a gap in reliable in vitro methods that closely recapitulate human cell behavior in a physiological-in vivo relevant fashion. Therefore, in this data set we set up to bench mark a detailed ...
ORGANISM(S): Homo sapiens 
2022-10-20 | E-MTAB-12266 | biostudies-arrayexpress
MetabolomicsSalmonella Modulates Metabolism during Growth under Conditions that Induce Expression of Virulence Genes
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a facultative pathogen that uses complex mechanisms to invade and proliferate within mammalian host cells. To investigate possible contributions of metabolic processes to virulence in S. Typhimurium grown under conditions known to induce ex...
2013-05-02 | MTBLS35 | MetaboLights
UnknownChromatin remodeling of histone H3 variants underlies epigenetic inheritance of DNA methylation.
Not available
S-EPMC10369972 | biostudies-literature
UnknownChromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation.
Not available
S-EPMC10529913 | biostudies-literature
Sort   by:  
 Page size