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TranscriptomicsNovel kinase fusion oncogenes in post-Chernobyl radiation-induced pediatric thyroid cancers
Exposure to ionizing radiation during childhood markedly increases the risk of developing papillary thyroid cancer. We identified non-overlapping somatic driver mutations in all 26 cases of post-Chernobyl thyroid cancers we studied through candidate gene assays and next generation RNA-sequencing. We...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-48850 | biostudies-arrayexpress
TranscriptomicsERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors
In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. Here we show that ERK5 regulates muscle cell fusion through Klf transcription factors. The inhibition ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-25827 | biostudies-arrayexpress
TranscriptomicsCell Fusion Enhances Mesendodermal Differentiation of Human Induced Pluripotent Stem Cells.
Human induced pluripotent stem cells (iPS cells) resemble embryonic stem cells and can differentiate into cell derivatives of all three germ layers. However, frequently the differentiation efficiency of iPS cells into some lineages is rather poor. Here, we found that fusion of iPS cells with human h...
ORGANISM(S): Homo sapiens 
2014-08-06 | E-GEOD-58457 | biostudies-arrayexpress
TranscriptomicsDiverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms
Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans Cell (LCH) and non-Langerhans (non-LCH) histiocytoses, respectively. The discovery of BRAFV600E mutations in ~50% of these patients pr...
ORGANISM(S): Homo sapiens 
2015-11-11 | E-GEOD-74442 | biostudies-arrayexpress
ProteomicsTargeting kinome reprogramming in ESR1 fusion-driven metastatic breast cancer
Transcriptionally active ESR1 fusions promote endocrine therapy (ET)-resistant growth and metastasis of estrogen receptor-alpha positive (ERα+) breast cancer. Currently, there are no targeted treatment options for tumors harboring active fusions because the ESR1 ligand binding domain (LBD) has been ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD033339 | Pride
Breast cancer Esr1 fusion Kinase 
ProteomicsMouse myoblast fusion - Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190
The p38 MAP kinases play critical roles in skeletal muscle biology, but the specific processes that they regulate remain poorly defined. Here we find that activity of p38α/β is important not only for early phases of myoblast differentiation, but also in later stages of myocyte fusion and myofibrill...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD002413 | Pride
Mouse Myoblast Differentiation Fusion 
TranscriptomicsA new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion
The identification of subtype-specific translocations has revolutionized diagnostics of sarcoma and provided new insight into oncogenesis. We used RNA-Seq to investigate samples diagnosed as small round cell tumors of bone, possibly Ewing sarcoma, but lacking the canonical EWSR1-ETS translocation. A...
ORGANISM(S): Homo sapiens 
2012-03-03 | E-GEOD-34800 | biostudies-arrayexpress
TranscriptomicsTelomere dysfunction and fusion during the progression of chronic lymphocytic leukaemia: evidence for a telomere crisis
We performed single-molecule telomere length and telomere fusion analysis in patients at different stages of chronic lymphocytic leukaemia (CLL). Our work identified the shortest telomeres ever recorded in primary human tissue reinforcing the concept that there is significant cell division in CLL. F...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-22016 | biostudies-arrayexpress
GenomicsA kinase fusion protein from Aegilops longissima confers resistance to wheat powdery mildew
A kinase fusion protein from Aegilops longissima confers resistance to wheat powdery mildew
PRJEB63085 | ENA
TranscriptomicsCleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF-{kappa}B Activation
Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated ly...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-25527 | biostudies-arrayexpress
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