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ProteomicsDecreased antibiotic susceptibility driven by global remodeling of the Klebsiella pneumoniae proteome
Bacteria can circumvent the effect of antibiotics by transitioning to a poorly understood physiological state that does not involve conventional genetic elements of resistance. Here we examine antibiotic susceptibility with a Class A β-lactamase+ invasive strain of Klebsiella pneumoniae that was iso...
ORGANISM(S): Klebsiella pneumoniae 
2019-03-14 | PXD010244 | Pride
Klebsiella pneumoniae proteome Antibiotics 
ProteomicsLon Protease-Mediated Secretome Profiling in Klebsiella pneumoniae
Lon protease is a global regulator in bacteria, affecting biofilm formation, antibiotic resistance, toxin-antitoxin complexes and proteolysis of damaged proteins. This study uses bottom-up proteomics to identify Klebsiella pneumoniae proteins with altered secretion patterns in the absence of lon and...
ORGANISM(S): Klebsiella pneumoniae 
2024-11-01 | PXD057415 | Pride
Klebsiella Pneumoniae Bacteria Iron Secretome 
ProteomicsQuantitative proteomics of iron limitation in Klebsiella pneumoniae
Nutrient adaptation is key in limiting environments for the promotion of microbial growth and survival. In microbial systems, iron is an essential component for many cellular processes and bioavailability varies greatly among different conditions. In the bacterium, Klebsiella pneumoniae, the impact ...
ORGANISM(S): Klebsiella pneumoniae 
2020-03-09 | PXD015623 | Pride
Quantitative proteomics Lon protease Iron limitation Klebsiella pneumoniae Secretome 
ProteomicsDeep phosphoproteomics of Klebsiella pneumoniae reveals HipA-mediated tolerance to ciprofloxacin
Klebsiella pneumoniae belongs to the group of bacterial pathogens causing the majority of antibiotic-resistant nosocomial infections worldwide; however, the molecular mechanisms underlying post-translational regulation of its physiology are poorly understood. Here we perform a comprehensive analysis...
ORGANISM(S): Klebsiella pneumoniae subsp. pneumoniae Escherichia coli 
2024-11-21 | PXD051521 | Pride
Phosphoproteome  klebsiella pneumoniae  antibiotic tolerance  persistence  mass spectrometry 
ProteomicsProteome data of clinical Klebsiella pneumoniae
Proteome data of clinical Klebsiella pneumoniae and two reference strains after growth in urine mimicking medium
ORGANISM(S): Klebsiella pneumoniae KP-1 
2025-08-13 | PXD047744 | Pride
Clinical isolates Proteomics Mass spectrometry Klebsiella pneumoniae 
ProteomicsProteome analysis of Klebsiella pneumoniae under infection-mimicking conditions
Whole bacterial proteome and secretome analysis of Klebsiella pneumoniae under the infection-mimicking conditionsoxidative stress and heat stress in chemically defined medium
ORGANISM(S): Klebsiella pneumoniae ATCC BAA-2146 
2025-04-14 | PXD052921 | Pride
Lipoproteinsklebsiella pneumoniae Oxidative stress Outer membrane proteins Global quantitative proteomics Klebsiella pneumoniae Heat stress Lipoproteins 
ProteomicsKlebsiella pneumoniae x546,ATCC15380, TMT
Klebsiella pneumoniae x546,ATCC15380, TMT,The samples were ground into a powder in liquid nitrogen. Then the powder was suspended in lysis buffer [1% sodium deoxycholate (SDS), 8M urea]. The mixture was allowed to settle at 4 鎺矯 for 30 min during which the sample were vortexed at every 5 min, and tr...
ORGANISM(S): Klebsiella pneumoniae subsp. pneumoniae DSM 30104 = JCM 1662 = NBRC 14940 Klebsiella pneumoniae Klebsiella pneumoniae MGH 78578 
2021-11-15 | PXD028396 | Pride
Atcc15380 Tmt Klebsiella pneumoniae x546 
ProteomicsKlebsiella pneumoniae protomic response to antibiotics
Bacteria can circumvent the effect of antibiotics by transitioning to a poorly understood physiological state that does not involve conventional genetic elements of resistance. Here we examine antibiotic susceptibility with a Class A β-lactamase+ invasive strain of Klebsiella pneumoniae that was iso...
ORGANISM(S): Klebsiella pneumoniae 
2019-03-14 | PXD009175 | Pride
Doxycycline Streptomycin Klebsiella pneumoniae Lc-ms/ms 
ProteomicsCoexistence of Klebsiella pneumonia biofilms with Candida albicans in an acute pneumonia
Coexistence of polymicrobial organisms acted as biofilm communities has become more and more prominent that these interactions lead to an increased resistance against host immune responses and antimicrobial agents, especially bacterial-fungal interactions. Klebsiella pneumoniae and Candida albicans ...
ORGANISM(S): Candida albicans (Yeast) 
2025-05-13 | PXD050494 | Pride
Klebsiella pneumonia Pneumonia Biofilm formation Candida albicans Neutrophil extracellular traps 
ProteomicsComparative proteomics demonstrates altered Metabolism pathways in cotrimoxazole-resistant and amikacin-resistant Klebsiella pneumoniae isolates
The emergence and spread of carbapenem-resistant Klebsiella pneumoniae (CR-KPN) infections have worsened the current situation worldwide. Clinically, cotrimoxazole (CTX) and amikacin (AMI) are considered to be the preferred drugs in the treatment of (CR-KPN). But for now, the extensive use of cotrim...
ORGANISM(S): Klebsiella pneumoniae ATCC 43816 
2021-11-25 | PXD028544 | Pride
Comparative proteomics Amikacin，cotrimoxazole Bioinformatics Klebsiella pneumoniae 
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