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MetabolomicsPolyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

In cancer, metabolic changes and uncontrolled tumor growth alter nutrient availability, impacting antitumor immune responses. Regulatory T (Treg) cells are a subset of T cells with immunosuppressive properties that has been found to additionally possess the ability to control tissue homeostasis a...

2025-07-24 | MTBLS12633 | MetaboLights
TranscriptomicsAnalysis of wildtype and Csnk2b-deficient Foxp3+ regulatory T cells transcriptomes
The goal of this study was to compare the transcriptional changes evoked by Csnk2b-deficiency in Foxp3+ regulatory T cells Messenger RNA profiles of CD4+Foxp3+ regulatory T cells isolated from 8 week old wild type (WT) and Csnk2b-deficient mice were generated by deep sequencing in duplicate, using I...
ORGANISM(S): Mus musculus 
2015-01-13 | E-GEOD-63961 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of antigen-specific T cells upon CCR9 knockdown in MCF7 cells.
Tumor cells are known to express immune-inhibitory ligands on their surface to mediate resistance against cytotoxic T lymphocytes. Using a high-throughput RNAi screening assay, we identified CCR9 as a potent tumor-specific immune checkpoint molecule that inhibited T cell-mediated tumor lysis. To und...
ORGANISM(S): Homo sapiens 
2015-02-19 | E-MTAB-3244 | biostudies-arrayexpress
TranscriptomicsAnalysis of bone marrow derived mast cell transcriptomes in presence or absence of SialostatinL
Goal of this study was to compare transcriptional changes in stimulated mast cells in the absence or presence of sialostatinL mRNA profiles of 4 weeks old mast cells (BMMC derived from C57BL/6 mice ) stimulated for 24h with ionomycin in absence or presence of tick derived sialostatinL were generated...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-66966 | biostudies-arrayexpress
TranscriptomicsAn RNASeq normal tissue atlas for mouse and rat
The function of a gene is closely connected to its expression specificity across tissues and cell types. RNA-Seq is a powerful quantitative tool to explore genome wide expression. The aim of the present study is to provide a comprehensive RNA-Seq dataset across the same 13 tissues for mouse and rat,...
ORGANISM(S): Rattus norvegicus 
2017-10-25 | E-MTAB-6081 | biostudies-arrayexpress
TranscriptomicsGlobal profiling of gene expression in the ΔdigR and ΔsgmT mutant of Myxococcus xanthus
In Myxococcus xanthus 55% of the more than 250 two-component signal transduction systems (TCS) genes are orphan. We hypothesized that the histidine kinase SgmT and the response regulator DigR, which comprises a DNA binding domain of the HTH_Xer type, function together to regulate gene expression. We...
ORGANISM(S): Myxococcus xanthus 
2012-05-17 | E-GEOD-34408 | biostudies-arrayexpress
UnknownFibrostenotic eosinophilic esophagitis might reflect epithelial lysyl oxidase induction by fibroblast-derived TNF-α.
Not available
S-EPMC6586527 | biostudies-literature
TranscriptomicsGATA-1-regulated erythroid microRNAs
We employed a gene complementation strategy combined with microarray screening to identify miRNAs involved in the formation of erythroid (red blood) cells. To search for GATA-1-regulated erythroid miRNAs, we used the Gata-1– erythroblast line G1E. These cells proliferate in culture as immature ery...
ORGANISM(S): Mus musculus 
2008-02-05 | E-GEOD-10134 | biostudies-arrayexpress
UnknownA Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer.
Not available
S-EPMC7566474 | biostudies-literature
UnknownAllelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33.
Not available
S-EPMC12044007 | biostudies-literature
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