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ProteomicsIdentification of X-linked genes that drive sex differences in murine embryonic stem cells
Dosage imbalance of X-chromosomal genes contributes to sex differences, in particular during early development, when both X chromosomes are active in females. X-encoded inhibitors of the differentiation-promoting MAP kinase (MAPK) signalling pathway slow down development, increase levels of naive pl...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-18 | PXD016729 | Pride
Klhl13 Sex differences Pluripotency Differentiation Mapk Mouse embryonic stem cells 
ProteomicsIdentification of X-linked genes that drive sex differences in murine embryonic stem cells
Dosage imbalance of X-chromosomal genes contributes to sex differences, in particular during early development, when both X chromosomes are active in females. X-encoded inhibitors of the differentiation-promoting MAP kinase (MAPK) signalling pathway slow down development, increase levels of naive pl...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-18 | PXD017875 | Pride
Klhl13 Sex differences Pluripotency Differentiation Mapk Mouse embryonic stem cells 
GenomicsRNA sequencing of Dusp9 and Klhl13 mutants in 1.8 female mouse embryonic stem cells (mESCs)
RNA sequencing of Dusp9 and Klhl13 mutants in 1.8 female mouse embryonic stem cells (mESCs)
PRJNA596761 | ENA
UnknownDeficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation.
Not available
S-EPMC6827317 | biostudies-literature
UnknownRHOBTB2 enhances cell proliferation of acute myeloid leukemia by modulating Hippo-YAP1 signaling and dependent of KLHL13.
Not available
S-EPMC12534508 | biostudies-literature
TranscriptomicsRNA sequencing of Dusp9 and Klhl13 mutants in 1.8 female mouse embryonic stem cells (mESCs)
Dosage imbalance for X-chromosomal genes contributes to sex differences, in particular during early development, when both X chromosomes are active in females. X-encoded inhibitors of the differentiation-promoting MAP kinase (MAPK) signalling pathway slow down development, increase levels of naive p...
ORGANISM(S): Mus musculus 
2021-03-16 | GSE142349 | GEO
ProteomicsAtg16L1 deficiency induces insulin resistance through KLHL9-KLHL13-CUL3 complex-mediated IRS1 degradation
Data contains LC-MS data of proximity-based biotin labeling assay (BioID) to generate the protein interaction network of KLHL9 and KLHL13 proteins fused to FlagBirA (N-terminal tag) and expressed in T-REx HEK293 cells.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-04-02 | MSV000083653 | MassIVE
ProteomicsBurkholderia pseudomallei BipD hijacks host KLHL9/KLHL13/CUL3 E3 ligase to ubiquitinate IMMT that initiates mitophagy to evade killing
Mitophagy is critical for mitochondrial quality control and function to clear damaged mitochondria. Here, we found that Burkholderia pseudomallei maneuvered host mitophagy for its intracellular survival through the type Ⅲ secretion system needle tip protein BipD. We identified BipD, interacting with...
ORGANISM(S): Homo Sapiens Acyrthosiphon Pisum 
PXD051631 |
TranscriptomicsRNA sequencing of 1.8 female mouse embryonic stem cells (mESCs) and XO subclones.
Dosage imbalance for X-chromosomal genes contributes to sex differences, in particular during early development, when both X chromosomes are active in females. X-encoded inhibitors of the differentiation-promoting MAP kinase (MAPK) signalling pathway slow down development, increase levels of naive p...
ORGANISM(S): Mus musculus 
2021-03-16 | GSE142348 | GEO
UnknownBurkholderia pseudomallei BipD modulates host mitophagy to evade killing.
Not available
S-EPMC11150414 | biostudies-literature
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