Sort   by:  
 Page size 
TranscriptomicsTranscriptional profile of the tail of zebrafish deiodinase knockdown
The role of deiodinase-mediated TH effects in early vertebrate development is only partially understood. Therefore, we investigated the role of deiodinases during early development of zebrafish until 96 hours post fertilization at the level of the transcriptome, biochemistry, morphology and physiolo...
ORGANISM(S): Danio rerio 
2015-04-10 | E-GEOD-61624 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of the abdomen of zebrafish deiodinase knockdown
The role of deiodinase-mediated TH effects in early vertebrate development is only partially understood. Therefore, we investigated the role of deiodinases during early development of zebrafish until 96 hours post fertilization at the level of the transcriptome, biochemistry, morphology and physiolo...
ORGANISM(S): Danio rerio 
2015-04-10 | E-GEOD-61623 | biostudies-arrayexpress
TranscriptomicsLiver Cyprinus carpio PFOS experiment
Perfluorooctane sulfonate (PFOS) has been manufactured for over 50 years in increasing quantities and has been used for several industrial and commercial aims. Due to the persistence and the bioaccumulation of this pollutant, it can be found worldwide in wildlife and humans. Biochemical effects of P...
ORGANISM(S): Cyprinus carpio 
2008-08-15 | E-GEOD-10980 | biostudies-arrayexpress
TranscriptomicsMechanistic evaluation of the insulin response in H4IIE hepatoma cells: New endpoints for toxicity testing?
Transcriptional profiling of insulin exposed H4IIE cells at different time points (6h-24h) to 100 nM insulin, with untreated solvent control cells (blanks). The central role of hepatic insulin resistance in pandemic metabolic diseases urges investigation of the underlying mechanisms of its developme...
ORGANISM(S): Rattus norvegicus 
2012-06-17 | E-GEOD-35697 | biostudies-arrayexpress
TranscriptomicsStressor mRNA expression profiling of three different stressors in the water flea Daphnia magna
Microarray analyses were used to evaluate patterns of gene transcription following exposure of the waterflea Daphnia magna to two natural and one anthropogenic stressor. cDNA microarrays compiled of three life stage specific and three stressor-specific EST libraries, yielding 1734 different EST sequ...
ORGANISM(S): Daphnia magna 
2013-09-01 | E-GEOD-24322 | biostudies-arrayexpress
TranscriptomicsMechanistic analysis of the model obesogen Tributyltin in the 3T3-L1 cell line
Obesogenic compounds are chemicals that might have an influence on obesity development through in utero or chronic lifetime exposure. Tributyltin (TBT) is one of the most studied obesogenic compounds, inducing adipogenesis in vitro and increasing body fat after in utero exposure of mice. This study ...
ORGANISM(S): Mus musculus 
2013-02-25 | E-GEOD-41340 | biostudies-arrayexpress
TranscriptomicsEcdysone signaling and transcript signature in Drosophila cells resistant against methoxyfenozide
Methoxyfenozide (RH-2485) represents the group of non-steroidal ecdysteroid agonists with a dibenzoylhydrazine structure, that are used as novel biorational insecticides in the control of insect pests. Here we report on the selection of Drosophila melanogaster S2 cells for resistance to inhibition o...
ORGANISM(S): Drosophila melanogaster 
2010-11-08 | E-GEOD-17748 | biostudies-arrayexpress
TranscriptomicsToxicogenomics in the 3T3-L1 cell line, a new approach for screening of obesogenic compounds
The obesogen hypothesis states that exposure to environmental compounds early in life or throughout lifetime might have an influence on obesity development. In this paper a new approach for obesogen screening is proposed, namely the use of transcriptomics in the 3T3-L1 pre-adipocyte cell line. Based...
ORGANISM(S): Mus musculus 
2014-05-01 | E-GEOD-53004 | biostudies-arrayexpress
TranscriptomicsGene expression changes in murine ileum during inflammation: Controls vs. intestinal schistosomiasis and TNBS-ileitis.
Background: Although a number of intestinal inflammatory conditions pertain to the ileum, whole-genome gene expression analyses on ileal inflammation in animal models are lacking to date. Therefore, we aimed to identify and characterize alterations in gene expression in the acutely inflamed ileum of...
ORGANISM(S): Mus musculus 
2012-10-05 | E-GEOD-31265 | biostudies-arrayexpress
TranscriptomicsPhysiological, biochemical and genome-wide transcriptional analysis reveals that elevated CO2 mitigates the impact of combined heat wave and drought stress in Arabidopsis thaliana at multiple organizational levels
Genome-wide transcriptional profiling of Arabidopsis thaliana to a combination of heatwave and drought under ambient and elevated CO2. Goal of this study was elucidate the transcriptional responses to a combination of heat wave and drought, and to see how these responses are modifed under future cl...
ORGANISM(S): Arabidopsis thaliana 
2014-04-24 | E-GEOD-57035 | biostudies-arrayexpress
Sort   by:  
 Page size