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ProteomicsPCMT1 generates the C-terminal cyclic imide degron on CRBN substrates
The E3 ligase substrate adapter cereblon (CRBN), the primary target of clinical agents thalidomide and lenalidomide, recognizes endogenous substrates bearing the C-terminal cyclic imide modification. Although C-terminal cyclic imides can form spontaneously, an enzyme that regulates the formation of ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-12-05 | PXD061730 | Pride
Crbn Pcmt1 C-terminal cyclic imide Glul Ppa1 
ProteomicsGenesis and regulation of C-terminal cyclic imides from protein damage
C-Terminal cyclic imides are post-translational modifications (PTMs) that can arise from spontaneous intramolecular cleavage of asparagine or glutamine residues resulting in a form of irreversible protein damage. These protein damage events are recognized and removed by the E3 ligase substrate adapt...
ORGANISM(S): Homo sapiens (Human) 
2024-08-08 | PXD054016 | Pride
Protein cleavage Cyclic imide Cereblon Protein damage Post-translational modifications Deamidation 
TranscriptomicsRNA-Seq in neurons from E16.5 mouse embryonic cortices from WT and SMCX KO mice
We conducted RNA-Seq (using Direct Ligation of Adapters to first strand cDNA) in neurons from E16.5 mouse embryonic cortices from WT and SMCX KO mice and harvested after 10 days in vitro culture. We sequenced RNA samples after 10 days in vitro cultures in biological and technical duplicates. 4 RNA s...
ORGANISM(S): Mus musculus 
2016-01-27 | E-GEOD-61024 | biostudies-arrayexpress
GenomicsChIP-Seq of H3K4 methylation in neurons isolated from E16.5 mouse embryonic cortices from WT and SMCX KO mice
We conducted ChIP-Seq of H3K4 methylation in neurons isolated from E16.5 mouse embryonic cortices from WT and SMCX KO mice and harvested after 10 days in vitro culture. We sequenced H3K4me1, H3K4me3 ChIP and Input samples from mouse embryonic cortical neurons cultured in vitro for 10 days. Experimen...
ORGANISM(S): Mus musculus 
2016-01-27 | E-GEOD-61023 | biostudies-arrayexpress
TranscriptomicsscRNAseq of olfactory mucosa and olfactory bulb of WT and Tspo knockout rats
We utilized single-cell RNA sequencing to examine gene expression changes in olfactory mucosa and olfactory bulb cells following knockout of translocator protein (18 kDa; Tspo) in Sprague Dawley rats. Tspo has been found to be highly expressed in the olfactory system in normal physiological conditio...
ORGANISM(S): Rattus norvegicus 
2026-10-09 | E-MTAB-15825 | biostudies-arrayexpress
TranscriptomicsEndocytic and signalling function of stabilin-1 in tumor associated macrophages
Stabilin-1 is a scavenger/sorting receptor expressed by sinusoidal endothelial cells, alternatively-activated and tumor-associated macrophages (TAM) in several types of human cancer and mouse tumor models. We have found abundant expression of stabilin-1 on TAM in mouse model of mammary adenocarcinom...
ORGANISM(S): Mus musculus 
2014-10-30 | E-GEOD-55595 | biostudies-arrayexpress
TranscriptomicsscRNA-seq study of hippocampal microglia, perivascular macrophages and perivascular fibroblasts in pre-plaque APP-KI mice
Aim of this experiment was to characterize whether SPP1 released from the hippocampal perivascular space could imprint microglia transcriptional states. We performed scRNA-seq analysis on sorted CD140a+ perivascular fibroblast (PVF), CD45highCD11intCD206+ perivascular macrophage (PVM) and CD45intCD1...
ORGANISM(S): Mus musculus 
2024-02-09 | E-MTAB-11918 | biostudies-arrayexpress
MetabolomicsIntegrated multi-omics analysis of adverse cardiac remodeling and metabolic inflexibility upon ErbB2 and ERRα deficiency
Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERRα also play key roles in heart physiology, and this approach could pose a potential liability to cardiovascular health. Herein, using integr...
2022-09-20 | MTBLS795 | MetaboLights
TranscriptomicsWhole transcriptome sequencing of splenic influenza-specific CD8+ T cells in wt and Notch1/2ko mice
To more specifically determine whether the TEC program is controlled by Notch, we generated molecular definitions of TECs and MPCs by whole transcriptome sequencing of sorted KLRG1-CD127+ and KLRG1+CD127- H-2 Db-NP specific CD8+ T cell populations from wild-type mice. These definitions were used to ...
ORGANISM(S): Mus musculus 
2014-10-26 | E-MTAB-2999 | biostudies-arrayexpress
TranscriptomicsGR and Klf15 regulate gene expression dynamics and integrate signals through feed forward circuitry
The glucocorticoid receptor (GR) regulates adaptive transcriptional programs that alter metabolism in response to stress. Network properties that allow GR to tune gene expression to match specific physiologic demands are poorly understood. We analyzed the transcriptional consequences of GR activatio...
ORGANISM(S): Mus musculus 
2013-05-13 | E-GEOD-44695 | biostudies-arrayexpress
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