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ProteomicsProteomic analysis of small extracellular vesicles (sEVs) derived from primary keratinocytes cultured in different calcium concentrations, treated with a peanut allergen extract and atopic dermatitis (AD)-relevant cytokines
Epidermal keratinocytes are key for maintenance of the integrity of the epidermis. One of the main drivers of keratinocyte differentiation is the calcium gradient; calcium concentration gradually increases towards the outer layers of the epidermis. Atopic dermatitis (AD) is a disorder associated wit...
ORGANISM(S): Homo sapiens (Human) 
2022-06-07 | PXD031729 | Pride
Extracellular vesicles Keratinocyte Atopic dermatitis Allergy 
ProteomicsProteomic analysis of filaggrin insufficient keratinocytes and secreted exosomes.
Filaggrin (FLG) is a key structural protein expressed in epidermal keratinocytes. Mutations in the filaggrin gene (FLG) are strongly linked to atopic dermatitis (AD) and allergic inflammation occurring later in life at distant body locations in AD patients. Keratinocytes secrete exosomes, small, lip...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD026859 | Pride
Exosomes Cd1a Keratinocyte Ichthyosis vulgaris Atopic dermatitis Filaggrin Lc-ms/ms 
ProteomicsProteomic analysis of small extracellular vesicles isolated from human blood plasma
Exosomes are small, lipid-rich membrane vesicles secreted by all nucleated cells. These vesicles carry a variety of cargo including nucleic acids, proteins and lipids. Due to their size and flexibility, exosomes can enter the circulation and therefore serve as means of communication between distant...
ORGANISM(S): Homo sapiens (Human) 
2023-06-07 | PXD036724 | Pride
Exosomes Extracellular vesicles Blood plasma 
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