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ProteomicsProteomic analysis of filaggrin insufficient keratinocytes and secreted exosomes.
Filaggrin (FLG) is a key structural protein expressed in epidermal keratinocytes. Mutations in the filaggrin gene (FLG) are strongly linked to atopic dermatitis (AD) and allergic inflammation occurring later in life at distant body locations in AD patients. Keratinocytes secrete exosomes, small, lip...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD026859 | Pride
Exosomes Cd1a Keratinocyte Ichthyosis vulgaris Atopic dermatitis Filaggrin Lc-ms/ms 
GenomicsGene expression profiling of filaggrin-insufficient keratinocytes exposed to inflammatory mediators and allergens
Gene expression profiling of filaggrin-insufficient keratinocytes exposed to inflammatory mediators and allergens
PRJNA839775 | ENA
TranscriptomicsGene expression profiling of filaggrin-insufficient keratinocytes exposed to inflammatory mediators and allergens
Loss-of-function mutations in the filaggrin gene are heavily associated with the incidence and severity of atopic dermatitis. Moreover, filaggrin insufficiency in epidermal keratinocytes can lead to persistent allergic inflammation and an associated immune response suggesting a role for this protein...
ORGANISM(S): Homo sapiens 
2022-05-20 | GSE203409 | GEO
UnknownFilaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.
Not available
S-EPMC7241785 | biostudies-literature
ProteomicsProteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased translation, keratinocyte-immune crosstalk and disordered axon guidance
Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads to atopic inflammation remain incompletely understood. Sk...
ORGANISM(S): Homo sapiens (Human) 
2019-08-14 | PXD014875 | Pride
Atopic eczema Skin Human 
ProteomicsUpregulation of filaggrin 2 in scleritis using tissue mass spectrometry
Scleritis is a severe inflammatory ocular disorder with unknown pathogenesis. Using a mass spectrometry approach, we investigated healthy sclera and sclera affected by non-infectious scleritis for differentially expressed proteins. Therefore, we collected scleral samples of enucleated eyes due to se...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038727 | Pride
Tissue Scleritis Nano-lcms Dda 
UnknownOrchestrated control of filaggrin-actin scaffolds underpins cornification.
Not available
S-EPMC5854575 | biostudies-literature
UnknownOne remarkable molecule: filaggrin.
Not available
S-EPMC3378480 | biostudies-literature
UnknownCutaneous Deficiency of Filaggrin and STAT3 Exacerbates Vaccinia Disease In Vivo.
Not available
S-EPMC5231274 | biostudies-literature
UnknownComparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins.
Not available
S-EPMC4437054 | biostudies-literature
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