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TranscriptomicsDevelopment of gene expression signatures for latent and clinical tuberculosis (TB)
For further identify the differentiation between latent and clinical tuberculosis (TB), we employed whole genome microarray expression profiling to study genes with significant expression change in peripheral CD4+T cells between healthy control, latent tuberculosis (LTB) and clinical tuberculosis (T...
ORGANISM(S): Homo sapiens 
2012-08-06 | E-GEOD-27882 | biostudies-arrayexpress
TranscriptomicsMycobacterium tuberculosis efpA CRISPRi knock-down transcriptional profile - induced efpA knock-down strain vs non-induced condition
In Mycobacterium tuberculosis, the efflux pump, EfpA, plays an essential but uncharacterised role in its physiology and antibiotic tolerance. In this study, an ATc-inducible CRISPR interference (CRISPRi) system was introduced into M. tuberculosis to knock-down the expression of efpA and determine an...
ORGANISM(S): Mycobacterium tuberculosis 
2024-06-19 | E-MTAB-13755 | biostudies-arrayexpress
UnknownAIDS-defining events among people living with HIV who have been under continuous antiretroviral therapy for more than one year, a German cohort study 1999-2018.
Not available
S-EPMC10954987 | biostudies-literature
UnknownSongbird nests on the ground as islands of diversity of ptyctimous mites (Acari: Oribatida) in the primeval Bialowieza Forest (Poland).
Not available
S-EPMC10406712 | biostudies-literature
TranscriptomicsDNA Methylation of gDNA from blood and bronchoalveolar lavage of tuburbulosis patients with and without type 2 diabetes via Illumina Infinium MethylationEPIC array
Tuberculosis (TB) remains a leading cause of illness and death globally. Type 2 diabetes (T2D) patients are more likely to become infected with Mycobacterium tuberculosis (M.tb). When they are infected, they are more likely to develop active TB disease and to present with more severe TB and those wh...
ORGANISM(S): Homo sapiens 
2025-12-14 | E-MTAB-16151 | biostudies-arrayexpress
UnknownSAMHD1's protein expression profile in humans.
Not available
S-EPMC7166976 | biostudies-literature
TranscriptomicsTranscription profiling by array of overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response
The Rv0805 gene in Mycobacterium tuberculosis encodes a metallophosphoesterase which shows cAMP-hydrolytic activity. Overexpression of Rv0805 has been used as a tool to lower intracellular cAMP levels and thereby elucidate the roles of cAMP in mycobacteria. Here we show that levels of cAMP in M. tub...
ORGANISM(S): Mycobacterium tuberculosis 
2013-11-02 | E-BUGS-146 | biostudies-arrayexpress
ProteomicsAxonal Tau sorting depends on the PRR2 domain and 0N4R-specific interactions hint at distinct roles of Tau isoforms in synaptic plasticity
Tau pathology is a major hallmark of Alzheimer’s disease (AD) and related diseases, called tauopathies. While Tau is normally enriched in axons, somatodendritic missorting of the microtubule-associated protein is a key event in early disease development. Tau missorting promotes synaptic loss and neu...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD053880 | Pride
Proline-rich region 2 Alzheimer’s disease Tau missorting Tau isoforms Synaptic tau Cdc42 Rab11 
UnknownExtended treatment of multimodal cognitive behavioral therapy in children and adolescents with obsessive-compulsive disorder improves symptom reduction: a within-subject design.
Not available
S-EPMC9737735 | biostudies-literature
TranscriptomicsTranscription profiling by tiling array of Potassium availability triggers Mycobacterium tuberculosis transition to, and resuscitation from, non-culturable (dormant) states
Dormancy in non-sporulating bacteria is an interesting and underexplored phenomenon with significant medical implications. In particular, latent tuberculosis may result from the maintenance of Mycobacterium tuberculosis bacilli in non-replicating states in infected individuals. Uniquely, growth of M...
ORGANISM(S): Mycobacterium tuberculosis 
2015-02-25 | E-BUGS-151 | biostudies-arrayexpress
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