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ProteomicsInflammatory signaling in human Tuberculosis granulomas is spatially organized
Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from TB patients in an unbiased fashion. Using laser capture microdissecti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080720 | MassIVE
ProteomicsOnline parallel accumulation – serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer
In bottom-up proteomics, peptides are separated by liquid chromatography with elution peak widths in the range of seconds, while mass spectra are acquired in about 100 microseconds with time-of-fight (TOF) instruments. This allows adding ion mobility as a third dimension of separation. Among several...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-11-06 | PXD010012 | Pride
Tims Pasef Technological 
ProteomicsProteome Profiling in Cerebrospinal Fluid Reveals Novel Biomarkers of Alzheimer’s Disease
Neurodegenerative diseases are a growing burden and there is an urgent need for better biomarkers for diagnosis, prognosis and treatment efficacy. Structural and functional brain alterations are reflected in the protein composition of cerebrospinal fluid (CSF). Alzheimer’s disease (AD) patients ha...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD016278 | Pride
Alzheimer’s disease/ cerebrospinal fluid/ mass spectrometry/ neurodegeneration/ proteomics 
ProteomicsProteome Profiling of Cerebrospinal Fluid reveals novel biomarker candidates for Parkinson’s disease
Parkinson's disease (PD) is a growing burden worldwide, and despite ongoing efforts to find reliable biomarkers for early and differential diagnosis, prognosis and disease monitoring, there is no biofluid biomarker used in clinical routine to date. Cerebrospinal fluid (CSF) is collected often and sh...
ORGANISM(S): Homo sapiens (Human) 
2022-06-01 | PXD026491 | Pride
Proteomics Csf Parkinson's disease Biomarker 
ProteomicsProteomic analysis of IDHmut gliomas suggests novel classification with greater separation than 1p/19q codeletion status
Glial cell-derived brain tumors (gliomas) are devastating diseases without effective curative therapies. Gliomas are classified according to various schemes including the cancer-initiating cell type, World Health Organization tumor grades, and genetic markers such as Isocitrate dehydrogenase (IDH) m...
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD024427 | Pride
Proteomics Glioma Glioblastoma Isocitrate dehydrogenase 1p/19q-codeletion 
ProteomicsProteome Profiling in Cerebrospinal Fluid Reveals Novel Biomarkers of Alzheimer’s Disease
Neurodegenerative diseases are a growing burden and there is an urgent need for better biomarkers for diagnosis, prognosis and treatment efficacy. Structural and functional brain alterations are reflected in the protein composition of cerebrospinal fluid (CSF). Alzheimer’s disease (AD) patients ha...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-06 | MSV000088649 | MassIVE
ProteomicsADAMTS12 serves as a checkpoint in fibrosis that controls migration and expansion of injury-responsive fibroblasts
Fibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-sequencing (scRNA-seq) technologies have helped elucidate fibroblast heterogeneity and ontogeny beyond fibroblast to myofi...
ORGANISM(S): Homo sapiens (Human) 
2024-07-01 | PXD040152 | Pride
Fibrosis Adamts12 Extracellular matrix 
TranscriptomicsInduced Pluripotent Mesenchymal Stromal Cell Clones Retain Donor-Derived Differences in DNA Methylation Profiles
Reprogramming of somatic cells into induced pluripotent stem cells (iPSC) is an epigenetic phenomenon. It has been suggested that iPSC retain some tissue-specific memory whereas little is known about inter-individual epigenetic variation of iPSC clones. In this study we have reprogrammed mesenchymal...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-GEOD-34688 | biostudies-arrayexpress
ProteomicsPD-1-targeted immunotherapy in NASH-triggered liver cancer induces pro-tumorigenic environment through CD8+PD-1+ T-cells
Immunotherapy has opened hitherto unknown possibilities to treat cancer. Whereas some cancer types (e.g. melanoma) can be efficiently treated, others lack measurable positive effects (e.g. PDAC). Moreover, stratification of responders/non-responders is only possible in some cancer types (e.g. melano...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-03 | PXD017236 | Pride
Immunotherapy Cd8+pd1+ Nash 
UnknownSpread of Terbinafine-Resistant Trichophyton mentagrophytes Type VIII (India) in Germany-"The Tip of the Iceberg?"
Not available
S-EPMC7712673 | biostudies-literature
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