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TranscriptomicsDKK1 expression is down-regulated in the lymph node pre-metastatic niche in esophageal cancer
Lymph node metastasis is a poor prognosis indicator in esophageal cancer. Although tumor spreading currently forms the main basis for therapy selection, the molecular mechanisms underlying the metastatic pathway remain insufficiently understood. Several studies aimed to investigate these mechanisms ...
ORGANISM(S): Homo sapiens 
2015-05-18 | E-GEOD-51021 | biostudies-arrayexpress
TranscriptomicsHuman thyroid adenomas, carcinomas, and normals
Human samples of various thyroid carcinomas, adenomas, and normals, each from a different patient, had mRNA assays performed using Affymetrix HG_U133A arrays, with 22283 probe-sets. The 99 samples consisted of 4 normals, 10 follicular adenomas, 13 follicular carcinomas, 7 oncocytic adenomas, 8 onco...
ORGANISM(S): Homo sapiens 
2011-02-09 | E-GEOD-27155 | biostudies-arrayexpress
UnknownUse of Chemical Hair Straighteners and Fecundability in a North American Preconception Cohort.
Not available
S-EPMC10505421 | biostudies-literature
TranscriptomicsTranscriptome analysis of JAK2wt and JAK2V617F+ iPSCs and iPSC-derived CD34+ progenitor-enriched cultures, either inflammatory cytokines treated or untreated.
PV-patient specific and control healthy individual-derived iPSCs were upon differentiation for 9 days into CD34+ hematopoietic progenitors treated with IFNγ, TNFα and TGFβ1 or untreated and used for transcriptome analysis. This dataset shows presence of cell-autonomous and strong non-cell autonomous...
ORGANISM(S): Homo sapiens 
2020-12-03 | E-MTAB-7693 | biostudies-arrayexpress
UnknownEvolutionary history of Polyneoptera and its implications for our understanding of early winged insects.
Not available
S-EPMC6386694 | biostudies-literature
TranscriptomicsTranscription profiling by array of mouse back skin of wild type and Range knockout animals after aceton treatment.
In order to identify critical changes in the genetic network of Rage signaling induced by TPA throughout a 48 h kinetic, global gene expression analysis was performed. Total RNA from untreated, 24h acetone- and 6, 12, 24, 48 h TPA-treated wt and Rage KO back skin was prepared (n=3 independent animal...
ORGANISM(S): Mus musculus 
2010-11-29 | E-MTAB-205 | biostudies-arrayexpress
TranscriptomicsGenome-wide control of RNA polymerase II activity by cohesin (tiling)
Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest changes in cohesin function that do not disrupt ch...
ORGANISM(S): Drosophila melanogaster 
2013-04-24 | E-GEOD-42360 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of MYC DNA-binding sites in Burkitt's lymphoma
Background: MYC is a transcription factor encoded by the c-MYC gene (thereafter termed MYC). MYC is key transcription factor involved in many central cellular processes including ribosomal biogenesis. MYC is overexpressed in the majority of human tumours including aggressive B-cell lymphoma especial...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30726 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of Patients with a Variation in the TNF-alpha gene and suffering from Multiple Trauma
BACKGROUND: Patients encountering severe trauma are at risk of developing sepsis syndrome and subsequent multiple organ failure. This is often associated with fatal outcome despite survival of the initial injury. We undertook a prospective cohort study of trauma patients to examine the role of tumor...
ORGANISM(S): Homo sapiens 
2007-08-22 | E-GEOD-5760 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for dog OCD samples
Obsessive-compulsive disorder (OCD), a severe mental disease manifested in time-consuming repetition of behaviors, affects 1-3% of the human population. While highly heritable, complex genetics has hampered attempts to elucidate OCD etiology. Dogs suffer from naturally occurring compulsive disorders...
ORGANISM(S): Canis lupus familiaris 
2013-12-20 | E-GEOD-53488 | biostudies-arrayexpress
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