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ProteomicsPhosphoproteomic analysis in Glioblastoma in response to AZD1775
The aim of this study was to characterize phosphoproteome in response to AZD1775 in patient derived xenografts (PDX) lines and clinical specimens in glioblastoma. Tyrosine and motif specific serine and threonine phosphorylation were measured using quantitative LC-MS/MS based on TMT labeling.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD018782 | Pride
Phosphoproteomics Azd1775 Glioblastoma 
ProteomicsSrc Family Kinases as potential therapeutic targets for chemotherapy-resistant triple negative breast cancer
Here we quantified tyrosine phosphorylation (pTyr) mediated signaling networks in chemotherapy sensitive (CS) and resistant (CR) TNBC patient derived xenografts (PDX) to gain novel therapeutic insights. We identified Src Family Kinases (SFKs) as potential therapeutic targets in CR TNBC PDXs. Additio...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034154 | Pride
Phosphoproteomics Breast cancer Phosphotyrosine Chemotherapy resistance Tnbc 
ProteomicsQuantitative analysis of tyrosine phosphorylation from FFPE tissues reveals patient specific signaling networks
The aim of this study was to characterize tyrosine phosphorylation from FFPE tissues. Global phosphoproteomics, global proteomics and tyrosine phosphorylation were measured using quantitative LC-MS/MS based on TMT labeling.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020284 | Pride
Lc-ms/ms Phosphotyrosine Ffpe Afatinib 
ProteomicsPhosphoproteomic response in nitrosamine-exposed mice
The aim of this study was to characterize ATM/ATR substrate motif specific phosphoproteome (phospho-SQ/TQ) in response to N-nitrosodimethylamine (NDMA) in mice. Motif specific phosphorylation were measured using quantitative LC-MS/MS based on TMT labeling.
ORGANISM(S): Mus musculus (Mouse) 
2021-02-10 | PXD021142 | Pride
Phospho-sq/tq Atm substrates Ndma 
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