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TranscriptomicsMicroarray analysis of serum mRNA in patients with head and neck squamous cell carcinoma
With the increasing demand for non-invasive approaches in monitoring of head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serum samples of HNSCC patients in comparison to healthy individuals. We compared gene expression ...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-MTAB-1516 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of JAK2wt and JAK2V617F+ iPSCs and iPSC-derived CD34+ progenitor-enriched cultures, either inflammatory cytokines treated or untreated.
PV-patient specific and control healthy individual-derived iPSCs were upon differentiation for 9 days into CD34+ hematopoietic progenitors treated with IFNγ, TNFα and TGFβ1 or untreated and used for transcriptome analysis. This dataset shows presence of cell-autonomous and strong non-cell autonomous...
ORGANISM(S): Homo sapiens 
2020-12-03 | E-MTAB-7693 | biostudies-arrayexpress
TranscriptomicsTranscriptome profile of peripheral blood mononuclear cells in patients with type I diabetes and their first grade relatives
Type 1 Diabetes (T1D) is considered to be a Th1 autoimmune disease characterised by an absolute lack of insulin caused by an autoimmune destruction of the insulin producing pancreatic beta cells. Th1 lymphocytes are responsible for the infiltration of the islets of Langerhans and for the cytokine re...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-29142 | biostudies-arrayexpress
TranscriptomicsActivation of normal dermal fibroblasts by normal and cancer epithelial cells: clinical samples.
We model processes of wound healing and tumor growth, by studying the effects of normal and cancer epithelial cells on normal fibroblasts and their reciprocal effect on normal keratinocytes in vitro. We find strong parallels between the two processes and compare our observations with transcriptional...
ORGANISM(S): Homo sapiens 
2013-11-02 | E-MTAB-1065 | biostudies-arrayexpress
TranscriptomicsActivation of normal dermal fibroblasts by normal and cancer epithelial cells. Tissue cultures.
We model processes of wound healing and tumor growth, by studying the effects of normal and cancer epithelial cells on normal fibroblasts and their reciprocal effect on normal keratinocytes in vitro. We find strong parallels between the two processes and compare our observations with transcriptional...
ORGANISM(S): Homo sapiens 
2013-11-02 | E-MTAB-1064 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of human head and neck squamous cell carcinoma to study the correlation between galectin-1 upregulation and the presence of SMA positive cancer-associated fibroblasts
In this study, we set the presence of smooth muscle actin (SMA)-positive cancer-associated fibroblasts (CAFs) in relation to galectin-1 and its in vivo competitor (galectin-3). In squamous cell carcinomas of head and neck, upregulation of galectin-1 presence is highly significantly correlated to pre...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-MTAB-850 | biostudies-arrayexpress
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