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ProteomicsEffect of MSC and MSC-derived extracellular vesicles on human blood coagulation
Mesenchymal stem cells (MSC) have emerged as potent therapeutic tool for a number of pathologies, including immune ones. However, unwelcome effects of MSC on the blood coagulation were revealed in some cases, which require more in-depth analysis. In this study, we explored the trombotic properties o...
ORGANISM(S): Homo sapiens (Human) 
2019-03-26 | PXD012768 | Pride
Human Mesenchymal stem cells Vesicles 
ProteomicsA First-Trimester Serum Proteomic Signature for Early Predic-tion of Preeclampsia: Integrated Untargeted and Targeted Mass Spectrometry with Machine Learning
First-trimester prediction of preeclampsia (PE) remains a major clinical challenge, par-ticularly outside specialized fetal medicine centers. This study aimed to identify and validate serum protein biomarkers for early PE prediction using an integrated proteo-mic approach. A prospective cohort of 64...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD080843 | Pride
Preeclampsia  first-trimester screening  serum proteomics  prognosis  dia-ms  mrm-ms  machine learning  biomarkers  complement system  mass spectrometry. 
ProteomicsPROTEOMIC CHARACTERIZATION OF DRY BLOOD SPOTS OF HEALTHY WOMEN DURING SIMULATION THE MICROGRAVITY EFFECTS USING DRY IMMERSION
This study is unique in that it was the first time that it was the female response to microgravity simulated by 3-day dry immersion that was analyzed. The result of the choice of the object of research fell on dry blood spots, since the technique of capillary blood sampling is less invasive and allo...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027654 | Pride
Human Healty human Mass-spectrometry Label-free Dry immersion 
ProteomicsTHE EFFECTS OF SPACE FLIGHT FACTORS ON THE HUMAN PLASMA PROTEOME, INCLUDING BOTH REAL SPACE MISSIONS AND GROUND-BASED MODEL EXPERIMENTS.
The aim of the study was to continue of the proteomic data accumulation on the effects of space flight factors on the human body, including ground-based model experiments. Blood plasma samples were collected from 5 healthy men included in the 21 days head-down bed rest experiment (HDBR) and 5 volun...
ORGANISM(S): Homo sapiens (Human) 
2019-07-04 | PXD013305 | Pride
Spaceflight Ground-base experiments Proteomics Mass-spectrometry Astronauts Dry immersion Head down bed rest Extreme conditions 
ProteomicsLC-MSMSMass Spectrometric detection of SARS-CoV-2 virus in scrapings of the epithelium of the nasopharynx of infected patients via Nucleocapsid N protein
Detection of viral RNA by PCR is currently the main diagnostic tool for COVID-191. The PCR-based test, however, shows limited sensitivity, especially at early and late stages of the disease development, and is relatively time consuming. Fast and reliable complementary methods for detecting the viral...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2020-08-14 | PXD019648 | Pride
Covid Covid-19 Proteomics Sars-cov-2 
ProteomicsTargeted MS based multi-omic analysis of blood plasma from COVID-19 patients to predict survival
Molecular signatures to discriminate patients based on risk of severe disease and mortality from COVID-19 infection are urgently required by the global medical community. Although non-targeted methods are useful for comprehensive ‘omic coverage, targeted MS-based approaches generally provide higher ...
ORGANISM(S): Homo Sapiens 
2022-08-18 | PXD027959 | panorama
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