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Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, INSERM UMR 1050, CNRS UMR 7241, INSERM UMR 944, CNRS UMR 7212, Université de Paris, IRSL, Hôpital St. Louis Paris France (1)
INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), Paris, France. (1)
Institut Curie, Paris Sciences et Lettres Research University, INSERM U934/ CNRS, UMR3215 (1)
Service d’hématologie Clinique et biologique, Hôpital Cochin, Paris. Université de Paris, Institut Cochin, Inserm U1016, Département Développement, Reproduction, Cancer, Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104 Paris (1)
Translational Research Centre in Onco-hematology, Faculty of Medicine, University of Geneva, and Swiss Cancer Center Leman, Geneva, Switzerland (1)

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Expression data from normal and MDS erythroids cell cutlures ex vivo

CD34 positive cells of bone marrow samples from normal and MDS samples were cultured ex vivo into erythroid conditions. We used microarrays to detail the gene expression programm of erythroid cells between normal and pathological (MDS) samples Mononuclear cells from bone marrow samples were selected...

ORGANISM(S): Homo sapiens

2012-02-14 | E-GEOD-34268 | biostudies-arrayexpress

Actinomycin targets NPM1c-primed mitochondria in AML

Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and association with favorable outcome remain incompletely understood. Here we demonstrate that an oncogenic mutant form of NPM1 (NPM1c) hampers formatio...

ORGANISM(S): Homo sapiens (Human)

2021-12-17 | PXD025507 | Pride