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ProteomicsGCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRASG12D-mutant cancer
KRAS mutation activates multiple intracellular signalling pathways, leading to tumour development and progression. However, whether KRAS mutations are involved in regulating ferroptosis in cancer and the underlying mechanism remains unclear. Here, we constructed stable KRASWT and KRASG12D-mutant cel...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD062451 | Pride
Krasg12d-mutant Lactylation Pdac 
UnknownEPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas.
Not available
S-EPMC8231095 | biostudies-literature
UnknownCo-targeting KRAS and Exportin1 as an effective therapeutic strategy for KRASG12D mutant pancreatic ductal adenocarcinoma.
Not available
S-EPMC12697726 | biostudies-literature
TranscriptomicsKras G12D Mutant vs. Wildtype
The experiment is a study of the effects of signal strength in the Ras pathway. In particular, we studied a gain-of-function mutant of Kras, KrasG12D. We generated these mutant mice and performed microarray analyses on RNA extracted from whole skin, comparing KrasG12D mice to wild-type mice, with th...
ORGANISM(S): Mus musculus 
2011-06-03 | E-MTAB-700 | biostudies-arrayexpress
ProteomicsMRTX1133 mechanism of action in KRASG12D mutant cancer cell lines by proteomics and single cell proteomics
diaPASEF proteomic analysis of KRASG12D mutant cell lines treated with MRTX1133. This dataset is part of a multiomic study featuring the metabolomics and single cell proteomics of 3,000 cells treated with drug. Files are broken into multiple repositories to simplify the deposition and reanalysis of ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-22 | MSV000091111 | MassIVE
TranscriptomicsPromotion of Lung Tumorigenesis By Beta-catenin
Although mutations in Kras are present in 21% of lung tumors, there is a high level of heterogeneity in phenotype and outcomes amongst lung cancer patients suggesting the importance of other pathways. Wnt/β-catenin signaling is a known oncogenic pathway that plays a well defined role in colon and sk...
ORGANISM(S): Mus musculus 
2011-01-28 | E-GEOD-26850 | biostudies-arrayexpress
MetabolomicsGNPS - MRTX1133 mechanism of action in KRASG12D mutant cancer cell lines by proteomics and single cell proteomics
diaPASEF proteomic analysis of KRASG12D mutant cell lines treated with MRTX1133. This dataset is part of a multiomic study featuring the metabolomics and single cell proteomics of 3,000 cells treated with drug. Files are broken into multiple repositories to simplify the deposition and reanalysis of ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-22 | MSV000091111 | GNPS
ProteomicsProteomic signatures induced by KRAS secondary mutation in AsPC1 cells
In this study, we performed a proteomic analysis to characterize differences in protein expression between KRASG12D secondary-mutant cell lines and KRASG12D single-mutant cell lines. Through systematic data analysis, we identified the key signaling pathways and regulatory proteins associated with re...
ORGANISM(S): Homo Sapiens 
2026-03-18 | PXD075786 |
MetabolomicsGlutamine-restricted diets restore sensitivity to KRASG12D inhibitor through the reversal of ANXA1-mediated metabolic reprogramming
This study investigates the mechanisms underlying KRASG12D inhibitor resistance and evaluates strategies to enhance treatment sensitivity. Our findings indicate that a glutamine-restricted diet not only reverses KRASG12D inhibitor resistance in PDAC but also achieves durable remission with long-term...
2026-06-27 | MTBLS14825 | MetaboLights
TranscriptomicsTranscription profiling of mouse 26-day-old K-ras conditional mutant mice and 3-month-old K-ras conditional mutant mice reveals cell-specific Kras and Pten mutations document proliferation arrest in granulosa cells vs. oncogenic insult to OSE cells
The small G-protein KRAS is crucial for mediating gonadotropin-induced events associated with ovulation. However, constitutive expression of KrasG12D in granulosa cells disrupted normal follicle development leading to the persistence of abnormal follicle-like structures containing non-mitotic cells....
ORGANISM(S): Mus musculus 
2009-05-27 | E-GEOD-16114 | biostudies-arrayexpress
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