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ProteomicsThe long non-coding RNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation
Numerous long non-coding RNAs (lncRNAs) were shown to have functional impact on cellular processes, such as human epidermal homeostasis, but for only a few the mode of action has been elucidated. Here, we report that lncRNA LINC00941 controls keratinocyte differentiation on a global level through as...
ORGANISM(S): Homo sapiens (Human) 
2024-04-08 | PXD043838 | Pride
Long non-coding rna Lc-msms Bivalency Differentiation Epidermis Nurd complex Linc00941 
TranscriptomicsOncogenic BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration [HT-seq]
Most cancer genomics papers to date have focused on aberrations in genomic DNA and protein-coding transcripts. However, around 50% of transcripts have no coding potential and may exist as non-coding RNA. We performed RNA-seq in BRAFv600e melanoma skin cancer and on melanocytes over-expressing oncoge...
ORGANISM(S): Homo sapiens 
2012-04-28 | E-GEOD-33092 | biostudies-arrayexpress
ProteomicsAnalysis of mouse glomerular cells
Protoemics of endothelia, podocytes, mesangial cells from mouse
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD016238 | Pride
Mouse 
ProteomicsResponse of podocytes to PAN - YAP-mediated mechanotransduction determines the podocyte's response to damage
Podocytes are terminally differentiated cells at the kidney filtration barrier and exposed to considerable mechanical strain. Podocyte injury causes morphological changes as a result of cytoskeletal reorganizations and failure of the filtration barrier. The transcriptional co-activators YAP/TAZ are ...
ORGANISM(S): Homo sapiens (Human) 
2017-04-19 | PXD003872 | Pride
Human podocytes pan 
ProteomicsProteomic analysis of glomeruli from Thsd7a podocyte knockout and WT mice
Proteomics experiment 1/3 associated with this work. THSD7A is a key podocyte antigen in membranous nephropathy (MN), an antibody-mediated autoimmune disease. While the pathogenic role of autoantibodies targeting THSD7A in MN is well described, the consequences of autoantibody binding for podocyte h...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-30 | PXD065322 | Pride
Podocyte injury Experimental membranous nephropathy Podocyte-specific knockout of thsd7a 
ProteomicsTHSD7A interactome in native mouse glomeruli
Proteomics experiment 2/3 associated with this work. THSD7A is a key podocyte antigen in membranous nephropathy (MN), an antibody-mediated autoimmune disease. While the pathogenic role of autoantibodies targeting THSD7A in MN is well described, the consequences of autoantibody binding for podocyte h...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-30 | PXD065323 | Pride
Ap-ms Interactome of thsd7a Podocyte injury Co-ip Experimental membranous nephropathy 
ProteomicsDeficiency of THSD7A reverses glomerular proteomic profiles in anti-THSD7A antibody induced membranous nephropathy models
Proteomics experiment 3/3 associated with this work. THSD7A is a key podocyte antigen in membranous nephropathy (MN), an antibody-mediated autoimmune disease. While the pathogenic role of autoantibodies targeting THSD7A in MN is well described, the consequences of autoantibody binding for podocyte h...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-30 | PXD065344 | Pride
Anti-thsd7a antibody induced membranous nephropathy Podocyte injury Experimental membranous nephropathy 
ProteomicsLongitudinal study of the small urinary extracellular vesicle proteome during living donor kidney transplantation
Urine was obtained from healthy kidney donors, from transplanted kidneys intrasurgery, at postoperative day 1 and at later timepoints. Exosomes were isolated and measured using nLC-MS/MS. For details, see the accompanying manuscript.
ORGANISM(S): Homo sapiens (Human) 
2021-08-30 | PXD005219 | Pride
Exosomes Transplantation Urine Human Kidney 
ProteomicsDeep mapping of the mouse podocyte proteome
We analyzed the proteome of mouse FACS-sorted podocytes. We compared podocytes ("green cells") with non-podocyte ("red cells") cells of the glomerulus.
ORGANISM(S): Mus musculus (Mouse) 
2018-06-21 | PXD003306 | Pride
Mouse Podocyte Kidney 
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