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ProteomicsThe lactate sensor NDRG3 decelerates ER-to-Golgi transport through interaction with the long isoform of syntaxin-5_2025
Authors: Pia E. Ferle, Niklas Krause, Judith Koliwer, Joern Michael Voelker, Fabia Becker, Alexander Hillebrand, Leonie F. Schroeder, Stefanie Jaeger, Seby Edassery, Dali Liu, Nevan Krogan, Jeffrey N. Savas, Gabriele Fischer von Mollard and Michael Schwake
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-11-04 | MSV000099757 | MassIVE
ProteomicsComparative Analysis of T Cell Spatial Proteomics and the Influence of HIV Expression
As systems biology approaches to virology have become more tractable, it has become possible to analyze highly studied viruses such as HIV in new, unbiased ways, including spatial proteomics. We have employed here a differential centrifugation protocol to fractionate an inducible model of HIV-expres...
ORGANISM(S): Homo sapiens (Human) 
2022-01-16 | PXD029956 | Pride
Spatial proteomics Hiv-1 Lc-ms/ms 
GenomicsPolycomb-like 3 is a PRC2 component that supports embryonic stem cell self-renewal
Polycomb repressive complex 2 (PRC2) trimethylates lysine 27 of histone H3 (H3K27me3), which regulates gene expression and controls diverse biological transitions in development, embryonic stem cell (ESC) differentiation, and cancer. Here we show that Polycomb-like 3 (Pcl3) is a component of PRC2 t...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-28325 | biostudies-arrayexpress
TranscriptomicsYeast X-Chromosome Associated Protein 5 (Xap5) Functions with H2A.Z to Suppress Aberrant Transcripts [ChIP-chip]
Comparison of occupancy profiling of Xap5 and H2A.Z/Pht1 in fission yeast. Agilent 60mer array was used to analyze DNA recovered by chromatin immunoprecipitation of Xap5 from fission yeast culture.
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-01 | E-GEOD-46505 | biostudies-arrayexpress
ProteomicsStructural insightsStructural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3 into regulation of the PEAK3 pseudokinase scaffold by 14-3-3
The three members of the PEAK family of pseudokinases (PEAK1, PEAK2, and PEAK3) are molecular scaffolds that have recently emerged as important nodes in signaling pathways that control cell migration, morphology, and proliferation, and are increasingly found mis-regulated in human cancers. While no...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD035574 | Pride
Human Ap-ms Lc-msms Peak3 
ProteomicsProteomic Organellar Mapping Identifies Modulation of Peroxisomes by HIV-1
The interaction between HIV-1 and the host cell has been studied at many levels, but cell-wide organellar changes caused by the virus have not been defined. Here, we aimed to detail perturbations to the host cell spatial proteome following HIV protein expression. Subcellular fractionation followed b...
ORGANISM(S): Homo sapiens (Human) 
2022-01-28 | PXD024716 | Pride
Lc-ms/ms Organelle mapping Proteomics Hiv-1 
TranscriptomicsYeast X-Chromosome Associated Protein 5 (Xap5) Functions with H2A.Z to Suppress Aberrant Transcripts [RNA-seq]
Functional characterization of the Xap5 protein using epistatic genetic interaction analysis (E-MAP), RNA-seq and ChIP-chip along with other growth experiments. wild type and mutant cells were grown at 37C in EMM50 and RNA was extracted from exponentially growing cells. Strand specific libraries wer...
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-01 | E-GEOD-46382 | biostudies-arrayexpress
TranscriptomicsYeast X-Chromosome Associated Protein 5 (Xap5) Functions with H2A.Z to Suppress Aberrant Transcripts
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-01 | E-GEOD-46506 | biostudies-arrayexpress
TranscriptomicsRNAPII CTD dataset
The C-terminal domain (CTD) of RNA polymerase II (RNAPII) is composed of heptapeptide repeats, which play a key regulatory role in gene expression. Using genetic interaction and mRNA expression analysis we found that truncating the CTD resulted in distinct changes to cellular function. Truncating th...
ORGANISM(S): Saccharomyces cerevisiae 
2013-09-13 | E-GEOD-43120 | biostudies-arrayexpress
ProteomicsCoronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication
Coronaviruses, including SARS-CoV-2, can cause severe disease in humans, whereas reservoir hosts like Rhinolophus bats appear to remain asymptomatic for reasons that are not well-recognized. To understand how host-specific protein-protein interactions (PPIs) shape infection outcomes, we generated co...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) Bat coronavirus RaTG13 Severe acute respiratory syndrome coronavirus 2 
2026-06-29 | PXD065873 | Pride
Host-pathogen interactions Ratg13 Sars-cov-2 Apms Bats 
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