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ProteomicsProteomic analysis of adipocyte insulin resistance
Insulin resistance is a major risk factor for human metabolic diseases including type 2 diabetes, cardiovascular diseases and some cancers. We analysed the proteome analyses across in vitro and in vivo models of insulin resistance to find common features of insulin resistance and identified lower e...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-07 | PXD005128 | Pride
Insulin resistance Mouse Adipocyte Adipose tissue Orbitrap Lc-ms/ms 
ProteomicsHuman adipose insulin resistance
Adipocytes play a major role in whole body fuel homeostasis. Integrated proteomic analysis of adipose from insulin resistant versus healthy humans or mice or in 3T3-L1 adipocytes revealed defects in the mevalonate/coenzyme Q (CoQ) biosynthesis pathway as a unifying feature of adipocyte insulin resis...
ORGANISM(S): Homo sapiens (Human) 
2018-02-09 | PXD006891 | Pride
Human obese adipose tissue insulin resistance 
UnknownThe transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes.
Not available
S-EPMC5789081 | biostudies-literature
UnknownKinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway.
Not available
S-EPMC4646237 | biostudies-literature
UnknownDynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin.
Not available
S-EPMC7005519 | biostudies-literature
UnknownMitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.
Not available
S-EPMC5800848 | biostudies-literature
Unknown14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.
Not available
S-EPMC5052641 | biostudies-literature
ProteomicsModelling complex cardiovascular disease in mature organoid model
Cardiac maturation is an important developmental phase where there are profound biological and functional changes after birth in mammals. Herein, we use our profiling of human heart maturation in vivo to identify key drivers of maturation in our human cardiac organoid (hCO) model. In this dataset, w...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD054791 | Pride
Cardiac organoids Maturation Dsp Cardiomyopathy 
ProteomicsCharacterisation of CASQ2 knockout cardiac organoid model
Cardiac maturation is an important developmental phase where there are profound biological and functional changes after birth in mammals. Herein, we use our profiling of human heart maturation in vivo to identify key drivers of maturation in our human cardiac organoid (hCO) model. In this dataset, w...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD055266 | Pride
Calsequesterin Crispr Cardiac organoids 
UnknownInsulin signaling requires glucose to promote lipid anabolism in adipocytes.
Not available
S-EPMC7504926 | biostudies-literature
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