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UnknownIntroduction of Chalcogenide Glasses to Additive Manufacturing: Nanoparticle Ink Formulation, Inkjet Printing, and Phase Change Devices Fabrication.
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S-EPMC8275797 | biostudies-literature
ProteomicsNew antiviral small molecule inhibitors disturb interactions between cellular HSP70 and virus proteins
RNA virus outbreaks such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), Ebola virus (EBOV) and Zika virus (ZIKV) causing worldwide health emergencies have highlighted the urgent need of new antiviral strategies. Upon outbreaks with new, unmet viruses where knowledge of virus biology...
ORGANISM(S): Homo sapiens (Human) Filoviridae Ebolavirus 
2021-01-04 | PXD021494 | Pride
Antiviral compound 2d-tpp Virus proteins Tpp Lc-msms 
ProteomicsRepurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms
To combat methicillin-resistant Staphylococcus aureus (MRSA) infections novel drugs addressing unprecedented and resistance-free targets are desperately needed. From a screen of human kinase inhibitors, we find that the anti-cancer drug sorafenib effectively kills MRSA strains. By dissection of the ...
ORGANISM(S): Staphylococcus aureus subsp. aureus NCTC 8325 
2022-01-19 | PXD008070 | Pride
Drug repurposing  antibacterial screening  bactericidal activity  spsb  staphylococcus aureus  mrsa  biofilm  persister  secretome  affinity-based protein profiling  chemical proteomics  photocrosslinker 
ProteomicsRepurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus
To combat methicillin-resistant Staphylococcus aureus (MRSA) infections novel drugs are desperately needed. From a screen, we found that the anti-cancer drug sorafenib effectively kills MRSA strains. By synthetic variation of key structural features, we identified a potent analog, PK150, exhibiting ...
ORGANISM(S): Staphylococcus aureus 
2019-09-09 | PXD012946 | Pride
Full proteome Affinity-based protein profiling (afbpp) Q exactive plus Chemical proteomics Staphylococcus aureus subsp. aureus nctc 8325 Secretome Surfaceome Orbitrap fusion 
ProteomicsThe heat shock response relies on orthogonal mechanisms to maintain protein homeostasis in yeast
We globally analyzed the heat stress response (HSR) in yeast on the transcriptomic, tranlatomic and the proteomic level. The cells were stressed at 37 °C, 42 °C and 46 °C and the fractionated proteomes measured on a Fusion mass spectrometer. With this approach we were able to reveal a modular charac...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-01-07 | PXD016125 | Pride
Chaperones Heat shock response Proteome Aggregation 
ProteomicsProteomics analysis of childhood acute lymphoblastic leukemia cell lines reveals novel drug vulnerabilities
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and it has a 5-year survival rate of 85% for European children. But for subsets of patients who fail to respond to standard of care chemotherapeutics, treatment options are limited, and clinical prognosis is poor. To establish a...
ORGANISM(S): Homo sapiens (Human) 
2022-03-26 | PXD023662 | Pride
Hirief Lc-msms All 
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