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ProteomicsASSESSING AUTOMATED SAMPLE PREPARATION TECHNOLOGIES FOR HIGH-THROUGHPUT PROTEOMICS OF FROZEN WELL CHARACTERIZED TISSUES FROM SWEDISH BIOBANKS
Large cohorts of carefully collected and stored clinical tissue materials play a central role in acquiring sufficient depth and statistical power to discover disease-related mechanisms and biomarkers of clinical significance. Manual preparation of such heterogeneous samples is labor intensive and re...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-11-27 | PXD011295 | Pride
Mass spectrometry clinical peoteomics 
ProteomicsASSESSING AUTOMATED SAMPLE PREPARATION TECHNOLOGIES FOR HIGH-THROUGHPUT PROTEOMICS OF FROZEN WELL CHARACTERIZED TISSUES FROM SWEDISH BIOBANKS
Large cohorts of carefully collected and stored clinical tissue materials play a central role in acquiring sufficient depth and statistical power to discover disease-related mechanisms and biomarkers of clinical significance. Manual preparation of such heterogeneous samples is labor intensive and re...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-11-27 | PXD010296 | Pride
Bravo assaymap Tissue Mass spectrometry Clinical proteomics Barocycler Bioruptor 
ProteomicsProteomic workflows for high quality quantitative proteome and PTM analysis of clinically relevant samples from FFPE archives
Well-characterized archival FFPE tissues are of much value for prospective biomarker discovery studies. Protocols that offer high-throughput and good reproducibility are essential in proteomics. Therefore, we developed a workflow implementing efficient paraffin removal and protein extraction from FF...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD021964 | Pride
Cancer Lung adenocarcinoma Suspension trapping (s-trap) Lysine acetylation stoichiometry Mass spectrometry Clinical proteomics Ffpe tissue Sample preparation High-throughput Isobaric labeling (tmt) 
ProteomicsProteomic workflows for high quality quantitative proteome and PTM analysis of clinically relevant samples from FFPE archives
Well-characterized archival FFPE tissues are of much value for prospective biomarker discovery studies. Protocols that offer high-throughput and good reproducibility are essential in proteomics. Therefore, we developed a workflow implementing efficient paraffin removal and protein extraction from FF...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD021986 | Pride
Cancer Lung adenocarcinoma Suspension trapping (s-trap) Lysine acetylation stoichiometry Mass spectrometry Clinical proteomics Ffpe tissue Sample preparation High-throughput Isobaric labeling (tmt) 
ProteomicsClinical proteomics workflow for high quality quantitative proteome and PTM analysis of biologically relevant FFPE tissue samples
In recent years, the use of formalin-fixed paraffin-embedded (FFPE) tissues has increased within cancer research and clinical proteomics. However, the use of FFPE tissues can be demanding due to paraffin embedding and cross-links introduced by the formaldehyde. Here, we developed a workflow implemen...
ORGANISM(S): Homo sapiens (Human) 
2020-12-18 | PXD020157 | Pride
Cancer Suspension trapping Lung adenocarcinoma Mass spectrometry Clinical proteomics Lysine acetylation stoichiomtery Throughput Proteomics Tissue Isobaric labeling Tmt Ffpe Sample preparation S-trap 
ProteomicsProteogenomics linked to histopathology identifies subtypes and progression biomarkers in malignant melanoma
In this study, proteogenomic analysis coupled with clinical histopathology revealed proteomic subtypes and identified candidate markers, which uncovered tumor biology related to patient survival. A total of 12,695 proteins and 45,356 phosphosites were quantified. This newly generated proteomic data ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD035206 | Pride
Cancer Proteomics Mass spectrometry Melanoma Proteogenomics Metastasis 
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