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UnknownThe Detrimental Clinical Associations of Anxiety and Depression with Difficult Asthma Outcomes.
Difficult asthma describes asthma in which comorbidities, inadequate treatment, suboptimal inhaler technique and/or poor adherence impede good asthma control. The association of anxiety and depression with difficult asthma outcomes (exacerbations, hospital admissions, asthma control, etc.) is unclea...
S-EPMC9142921 | biostudies-literature
UnknownProtocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic.

Background

Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of a number of biological targets and development of various novel therapies. Despite this, asthma still represents a significant health and economic burden worldwide. ...
S-EPMC6534885 | biostudies-literature
UnknownMultimorbidity phenotypes and associated characteristics in severe asthma: an observational study of European severe asthma registries.

Background

The phenotypic nature of multimorbidity in severe asthma is poorly understood. Our aims in this study were to define multimorbidity phenotypes and their characteristics in severe asthma across Europe by identifying and characterising co-aggregation of comorbidities.

Methods

S-EPMC12906202 | biostudies-literature
UnknownGene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies.

Background

Multiple environmental and genetic factors play a role in the pathogenesis of atopic eczema (AE). We aimed to investigate gene-environment interactions (G × E) to improve understanding of the pathophysiology.

Methods

We analysed data from 16 European studies to test for int...
S-EPMC12368900 | biostudies-literature
UnknownGene-environment interaction analysis in atopic eczema: evidence from large population datasets and modelling <i>in vitro</i>.

Background

Environmental factors play a role in the pathogenesis of complex traits including atopic eczema (AE) and a greater understanding of gene-environment interactions (G*E) is needed to define pathomechanisms for disease prevention. We analysed data from 16 European studies to test for...
S-EPMC12424891 | biostudies-literature
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