Sort   by:  
 Page size 
ProteomicsShotgun proteomics analysis of nuclear and mitochondrial from human coronary artery endothelial cells fraction treated with calcioprotein particles
Calciprotein particles (CPPs) are indispensable scavengers of excessive Ca2+ and PO43- ions in the blood, being internalized and recycled by liver and spleen macrophages, monocytes, and endothelial cells (ECs). Despite the fact, that CPPs are associated with many cardiovascular diseases and are know...
ORGANISM(S): Homo sapiens (Human) 
2023-12-31 | PXD047581 | Pride
Calciprotein particles Timstof pro Dda-pasef Mitochondria Endothelium Nucleus Subcellular fractionation 
ProteomicsCalciprotein particles cause physiologically significant pro- inflammatory response in endothelial cells and systemic circulation
Calciprotein particles (CPPs) represent self-assembling scavengers of excessive Ca2+ and PO43- ions which are formed in the human serum under the guidance of acidic proteins termed mineral chaperones (e.g., fetuin-A and albumin). While protecting the human organism from extraskeletal calcification, ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-30 | PXD038017 | Pride
Human Shotgun proteomics Timstof pro Calciprotein particles Calcium Endothelium 
ProteomicsProteolytic degradation is the culprit behind a bioprosthetic heart valve failure
Whereas the risk factors for structural valve deterioration (SVD) of glutaraldehyde (GA)- treated bioprosthetic heart valves (BHVs) are well-studied, those responsible for the failure of next-generation BHVs fixed with alternative chemicals remain largely unknown. Here, we collected 11 ethylene glyc...
ORGANISM(S): Homo sapiens (Human) 
2022-12-25 | PXD035113 | Pride
Human Pasef Timstof pro Calcific aortic valve disease Bioprosthetic heart valve 
ProteomicsProteomic profiling of carotid atherosclerotic plaques and adjacent intact arterial segments
Although it is well known that the extracellular matrix composition significantly impacts the development of neointimal hyperplasia and atherosclerosis, the biochemical cues regulating the cell-ECM interactions within the neointima remain obscure. Here, we pairwise collected 14 atherosclerotic plaqu...
ORGANISM(S): Homo sapiens (Human) 
2025-06-05 | PXD035173 | Pride
Atherosclerosis Timstof pro Diapasef Data-independent acquisition 
ProteomicsProteomic profiling of tissue-engineered, small-diameter vascular grafts implanted into the ovine carotid artery
Albeit vascular prostheses for the replacement of large arteries (e.g. aorta) are commercially available for decades, small-diameter vascular grafts (e.g., for coronary artery bypass graft surgery) still remain an unmet clinical need. Biostable polymers commonly used for the fabrication of aortic pr...
ORGANISM(S): Ovis aries 
2022-11-26 | PXD036520 | Pride
Shotgun proteomics Timstof pro Vascular grafts Ovis aries Sheep 
ProteomicsProteomics of endothelial cell secretome after exposure to calciprotein particles
Calciprotein particles (CPPs), assembled as a result of molecular interactions between fetuin-A and nascent calcium phosphate clusters, are indispensable scavengers of excessive Ca2+ and PO43– ions, thus representing an elegant mechanism which regulates mineral homeostasis. Generation of CPPs repres...
ORGANISM(S): Homo sapiens (Human) 
2024-10-24 | PXD055909 | Pride
Lc-ms/ms Inflammation Hcaec Calciprotein particles Hitaec Secretome 
ProteomicsPhysiological profile of the coronary artery and internal thoracic artery endothelial cells as a basis for the structural and functional congrunce of the arterio-arterial continuum
Currently, it is well established that human endothelial cells (ECs) are characterised by a significant heterogeneity between distinct blood vessels, e.g., arteries, veins, capillaries, and lymphatic vessels. Further, even ECs belonging to the same lineage but grown under different flow patterns (e....
ORGANISM(S): Homo sapiens (Human) 
2023-10-17 | PXD037861 | Pride
Endothelium Pasef Tims tof pro 
Sort   by:  
 Page size