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ProteomicsDefining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus
Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined. For the attaching and effacing (A/E) bacterial family member and murine pathogen Citrobacter rodentiu...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-17 | PXD061145 | Pride
Espc Mucus Air-liquid interface Colonoids Enteric pathogens 
ProteomicsMultimodal cell maps as a foundation for structural and functional genomics
Human cells contain a complex hierarchy of components, many of which remain uncharted. Here we broadly identify subcellular components across the 10–9–10–5 meter range, via self-supervised fusion of immunofluorescence images and biophysical interactions measured for >5100 proteins in U2-OS human cel...
ORGANISM(S): Homo sapiens (Human) 
2025-01-08 | PXD052362 | Pride
Size-exclusion chromatography Protein-correlation profiling Lcmsms 
ProteomicsProteome of the six eyes sand-spider Sicarius thomisoides venom
The six-eyed sand spider, Sicarius thomisoides, belongs to the Sicariidae family, whose venoms have recently been recognized for having a high toxic potential, similar to what has been demonstrated for the venom of spiders in the Loxosceles genus. However, with the exception of phospholipase D toxin...
ORGANISM(S): Sicarius thomisoides 
2025-11-10 | PXD062481 | Pride
Sicarius spider Venom proteome Lc-ms/ms 
TranscriptomicsTranscription profiling of human Ewings sarcoma cell line A673 inducible-rescue experiment
A673 Ewing's sarcoma cells, with inducible EWS/FLI cDNA, harboring the EF-2-RNAi retrovirus, induced (or uninduced) for the indicated time period. Experiment Overall Design: Two replicates of a time course series, including the indicated time points, including both induced and uninduced samples.
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4563 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of human Ewings sarcoma A673 Stable-Knockdown
A673 Ewing's sarcoma cells containing either control RNAi retroviral constructs (luc-RNAi), or RNAi retroviral constructs targeting the endogenous EWS/FLI fusion transcript (either EF-2-RNAi or EF-4-RNAi). Experiment Overall Design: Eight samples total. Four luc-RNAi, and four EWS/FLI knockdown con...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4560 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A673 Ewings sarcoma cells: stable-knockdown and inducible-rescue time course experiments
This SuperSeries is composed of the following subset Series:; GSE4560: A673 Stable-Knockdown; GSE4563: A673 inducible-rescue experiment Experiment Overall Design: Refer to individual Series
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4565 | biostudies-arrayexpress
TranscriptomicsGpx3 male transgenic liver expression vs B6/DBA male wildtype control
A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our m...
ORGANISM(S): Mus musculus 
2009-03-07 | E-GEOD-11997 | biostudies-arrayexpress
TranscriptomicsMucosal transcriptomics implicates under expression of FAM5C in the pathogenesis of ulcerative colitis
Background and aims: Mucosal abnormalities are potentially important in the primary pathogenesis of ulcerative colitis (UC). We investigated the mucosal transcriptomic expression profiles of biopsies from patients with UC and healthy controls (HC), taken from macroscopically non-inflamed tissue fr...
ORGANISM(S): Homo sapiens 
2014-09-05 | E-GEOD-48634 | biostudies-arrayexpress
UnknownVariable skeletal phenotypes associated with biallelic variants in <i>PRKG2</i>.
Not available
S-EPMC9554069 | biostudies-literature
UnknownCentral nervous system histoplasmosis: Multicenter retrospective study on clinical features, diagnostic approach and outcome of treatment.
Not available
S-EPMC5895412 | biostudies-literature
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