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ProteomicsA label-free shotgun proteomics analysis of macadamia nut
In this study, we present a first proteomic overview of macadamia nut using a label-free shotgun proteomic approach and prediction of their proteins with potential allergenic activity and cross-reactivity via an in silico analysis. The defense response proteins were the most abundant group of protei...
ORGANISM(S): Macadamia 
2020-01-13 | PXD015364 | Pride
Macadamia nut  label-free shotgun proteomics  in silico analysis  allergenicity  cross-reactivity 
ProteomicsLabel free mass spectrometry-based quantification of linker histone H1 variants in clinical samples
Epigenetic aberrations have been recognized as important contributors to cancer onset and development, and increasing evidence suggests that linker histone H1 variants may serve as biomarkers useful for patient stratification, as well as play an important role as drivers in cancer. Although traditio...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-16 | PXD020537 | Pride
Proteomics Mass spectrometry Label-free quantification Epigenetics Linker histone h1 Laser micro-dissection 
TranscriptomicsGlobal expression analysis of HNF4alpha and HNFgamma-mediated transcriptional control
Hepatocyte nuclear factor-4α (HNF4α, NR2A1) is a nuclear receptor which has a critical role in hepatocyte differentiation and the maintenance of homeostasis in the adult liver. However, a detailed understanding of native HNF4α in the steady state remains to be elucidated. Here we report the native H...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-18973 | biostudies-arrayexpress
ProteomicsQuantitative Label-free Comparison of the Metabolic Protein Fraction in Old and Modern Wheat Italian Genotypes by a Shotgun Approach
Wheat represents one of the most important cereals for mankind. However, since wheat proteins are also the causative agent of several adverse reactions, during the last decades, consumers have shown an increasing interest in the old wheat genotypes, which are generally perceived as more “natural” an...
ORGANISM(S): Triticum aestivum (Wheat) 
2021-05-13 | PXD024204 | Pride
Old and modern wheat genotypes  label-free quantitation  high-resolution mass spectrometry  proteome analysis  metabolic proteins 
UnknownCharacterization of the MDSC proteome associated with metastatic murine mammary tumors using label-free mass spectrometry and shotgun proteomics.
Not available
S-EPMC3154190 | biostudies-literature
ProteomicsLabel free quantitative mass spectrometry identifies platelet degranulation as an early event during platelet storage
Shelf life of platelet concentrates (PCs) is limited to up to 7 days due to loss of platelet functionality during storage, commonly referred to as the platelet storage lesion (PSL). To get more insight into the development of the PSL, we used label free quantitative mass spectrometry to identify cha...
ORGANISM(S): Homo sapiens (Human) 
2017-09-11 | PXD005610 | Pride
Proteomics Label free quantification Alpha-granules Platelet storage Platelets 
OtherA Combined Shotgun and Targeted Mass Spectrometry Strategy for Breast Cancer Biomarker Discovery.
Data from ProteomeXchange, PXD ID: PXD001685. File: B08-07165_c.mzml. Published as part of J Proteome Res. 2015 Jun 5 . From the Abstract: {{i} ... Eighty breast tumors, stratified for estrogen receptor status and development of distant recurrence (DR - ), were collected. After enrichment of N-glyc...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320015681 | GPMDB
Resource Reanalysis 
ProteomicsQuantitative Label Free Ultra Definition Mass-Spectrometry Provides Novel Data on the Proteomic Signature of Oral Squamous Cell Carcinoma
There are no early detection biomarkers or prognostic markers for oral squamous cell carcinoma (OSCC) thus many are detected late, with unpredictable disease course. Using systems level analysis on shotgun proteomics with quantitative label-free ultra-definition mass spectrometry, our study aims to ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD009244 | Pride
Oscc Tongue cancer Label-free proteomics Tissue proteomics 
ProteomicsA Combined Shotgun and Targeted Mass Spectrometry Strategy for Breast Cancer Biomarker Discovery
Metastasizing breast cancer is an incurable disease. Thus, it is important to find proteins responsible for tumor dissemination, which may be used as biomarkers or treatment targets. In this study, we established the combination of a non-targeted LC-MS/MS discovery and a targeted LC-SRM verification...
ORGANISM(S): Homo sapiens (Human) 
2015-06-16 | PXD001685 | Pride
Breast cancer Shotgun Mrm Distant recurrence Srm 
ProteomicsMorpheus Spectral Counter - Morpheus spectral counter: a computational tool for label-free quantitative mass spectrometry using the morpheus search engine
Label-free quantitative mass spectrometry (MS) based on the Normalized Spectral Abundance Factor (NSAF) has emerged as a simple and reasonably robust method to determine the relative abundance of individual proteins within complex mixtures. Here, we describe Morpheus Spectral Counter (MSpC) as the ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-02-24 | PXD003002 | Pride
Proteomics Morpheus Software Bioinformatics Spectral count Label-free quantification Lc-ms/ms 
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