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ProteomicsMyeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy
The anthracycline doxorubicin is a commonly used chemotherapeutic drug that induces cardiomyopathy in almost 10% of patients. The aim of this study was to examine the role of the leukocyte-derived enzyme Myeloperoxidase (MPO) in pathogenesis of anthracycline-induced Cardiomyopathy (AICM). We perform...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-30 | PXD037524 | Pride
Cardiotoxicity Polymorphonuclear neutrophils Aicm Mpo Doxorubicin 
ProteomicsProteomic analyses of non-preconditioned murine kidneys pre- and post-IRI in comparison to kidneys after preconditioning by hypoxia or caloric restriction
12 – 14-week-old male C57Bl6N mice were divided into 3 treatment groups (n=5). First, non-preconditioned animals received ad libitum access to food under a daily 12 hour light and 12 hour dark rhythm with similar specific pathogen free (SPF) conditions in group-cages with up to 5 mice at the same ti...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-13 | PXD024685 | Pride
Hypoxia Caloric restriction Ischemia-reperfusion injury Preconditioning 
ProteomicsThe let-7 family of miRNA mediates paternal intergenerational inheritance of metabolic disorders via post-transcriptional regulation of mitochondrial dynamics.
This study aims to investigate the molecular mechanisms and nature of impaired soma-germline crosstalk in IEI by focusing on the miRNA regulations in soma and sperm of obese male mice. We found that F0 HFD deteriorated glucose metabolism in F0 and F1, whereas F0 weight loss largely corrected glucose...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-06 | PXD042800 | Pride
Metabolic diseases Mitochondrial dysfunction Microrna Intergenerational epigenetic inheritance Let-7 
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