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TranscriptomicsThe effect of MPO inhibitor on the gene expression profiles in HL-60 cell lines exposed to 1, 2, 4,-benzenetriol
To reveal the gene expression profile changes after exposure to BT, one of benzene metabolites, with or without ABAH, a myeloperoxidase (MPO) inhibitor, and to elucidate how MPO is involved in myelotoxicity of BT, we performed microarray analysis. HL-60 cells suspended in RPMI 1640 containing with 1...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-50805 | biostudies-arrayexpress
ProteomicsComprehensive quantification of modifications of human and mouse myeloperoxidase by LC-MSMS
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic and refractory disease, characterized by necrotizing small to medium vessel vasculitides. AAV constitutes three distinct disorders: microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) (formerly k...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-04-21 | PXD050920 | Pride
Human Lc-msms Oxidative modification Mouse Myeloperoxidase 
ProteomicsLabel-free mass spectrometry analysis of laminin with induced oxidations and chlorination’s facilitated with hypochlorous acid and myeloperoxidase treatments.
Basement membranes are specialized extracellular matrices that underlie arterial wall endothelial cells, with laminin being a key structural and biologically-active component. Hypochlorous acid (HOCl), a potent oxidizing and chlorinating agent, is formed in vivo at sites of inflammation, via the enz...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-05 | PXD022056 | Pride
Ecm Lc-ms/ms Oxidation Extracellular matrix proteins Inflammation. Chlorination Laminin 
ProteomicsThe Bimodal Sugar Code of Neutrophil Myeloperoxidase
Myeloperoxidase (MPO), an important diprotomeric glycoprotein in neutrophil-mediated immunity, produces microbicidal hypohalous acids, but the underpinning glycobiology remains elusive. Deep characterisation of neutrophil-derived MPO (nMPO) using advanced mass spectrometry demonstrated that under-pr...
ORGANISM(S): Homo sapiens (Human) 
2021-03-07 | PXD021131 | Pride
Biosynthesis Granulopoiesis Degranulation Neutrophil Activity : myeloperoxidase N-glycosylation N-acetyl-β-d-glucosamine Ceruloplasmin Granule Inhibition 
GenomicsIntrarenal single cell sequencing of MPO-ANCA associated glomerulonephritis patients reveal novel targetable treatment options
Intrarenal single cell sequencing of MPO-ANCA associated glomerulonephritis patients reveal novel targetable treatment options
PRJNA956471 | ENA
GenomicsRemodelling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO [ATAC-seq]
Remodelling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO [ATAC-seq]
PRJNA837568 | ENA
GenomicsMPO/HOCl upregulates gene expression of mitophagy in murine macrophages
MPO/HOCl upregulates gene expression of mitophagy in murine macrophages
PRJNA1372004 | ENA
GenomicsRemodelling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO [3-end-Seq]
Remodelling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO [3-end-Seq]
PRJNA834059 | ENA
GenomicsMPO and TRH within leukemia stem cells increased chemosensitivity in acute myeloid leukemia
MPO and TRH within leukemia stem cells increased chemosensitivity in acute myeloid leukemia
PRJNA1004316 | ENA
TranscriptomicsIntrarenal single cell sequencing of MPO-ANCA associated glomerulonephritis patients reveal novel targetable treatment options
The etiopathogenesis underlying myeloperoxidase anti-neutrophil cytoplasmic antibody associated glomerulonephritis (MPO-AAGN) remains incompletely understood. Furthermore, there are only limited treatment options and treatment resistance of MPO-AAGN is still a common problem. To identify new targete...
ORGANISM(S): Mus musculus 
2024-01-01 | GSE229857 | GEO
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