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ProteomicsRegulation of Global Lysine Lactylation during HCMV Infection
Aerobic glycolysis is a hallmark of virus-infected cells, leading to substantial accumulation and secretion of lactate. However, the regulatory roles of lactate during viral infections are still poorly understood. Here, we report that human cytomegalovirus (HCMV) infection leverages lactate to induc...
ORGANISM(S): Cytomegalovirus Homo sapiens (Human) 
2024-11-23 | PXD057709 | Pride
Human cytomegalovirus Lysine lactylation Alanine Lactyllysine Aars1 
ProteomicsCyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome
Here we employed a non-enzymatic chemical labeling approach to introduce lactylation on lysine residues of model peptides and proteins. Tandem MS acquisition of lactylated peptide carriers on different MS platforms unequivocally led us to note an intense peak corresponding to the “cyclic” immonium ...
ORGANISM(S): Homo Sapiens 
2021-09-15 | PXD028488 |
ProteomicsGlobal Lysine Lactylation Dynamics during HCMV and HSV-1 Infections
Aerobic glycolysis is a hallmark of virus-infected cells, leading to substantial accumulation and secretion of lactate. However, the regulatory roles of lactate during viral infections are still poorly understood. Here, we report that human cytomegalovirus (HCMV) infection leverages lactate to induc...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 Human cytomegalovirus (HHV-5) (Human herpesvirus 5) 
2024-11-23 | PXD055230 | Pride
Hcmv Hsv-1 Lactyllysine Fibroblast Lactylation 
ProteomicsQuantification of lactylation in mouse peritoneal macrophages with or without stimulation of VSV by LS-MS/MS
Quantification of lactylation in mouse peritoneal macrophages with or without stimulation of VSV(12h) by LS-MS/MS, And lactylation peptides were enriched by Anti-Lactyllysine antibody conjugated agarose beads (PTM-1404, PTM Bio)
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD042171 | Pride
Vsv Quantification Mouse peritoneal macrophages Lactylation Lc-ms/ms 
UnknownClass I histone deacetylases (HDAC1-3) are histone lysine delactylases.
Not available
S-EPMC8769552 | biostudies-literature
ProteomicsLysine lactylation critically regulated energy metabolism of the protozoan parasite Trypanosoma brucei
Lysine lactylation, a new post-translational modification identified on histones of human and mouse cells, stimulates gene transcription from chromatin directly. However, very little is known in the scope and cellular distribution of lactylated proteins. In the present study, we conducted the first ...
ORGANISM(S): Trypanosoma brucei 
2021-10-01 | PXD023011 | Pride
Lysine lactylation  trypanosoma brucei  energy metabolism  glycolysis 
UnknownNonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses.
Not available
S-EPMC11770101 | biostudies-literature
ProteomicsWhole-protein lactylation proteome analysis of rat nucleus pulposus tissues
Lactate accumulation is a hallmark and contributing factor of intervertebral disc degeneration (IVDD). Lactate accumulation facilitates protein lactylation, while the role and mechanism of protein lactylation in IVDD remain unclear. In this study, we performed sequencing of the lactylation sites of ...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-13 | PXD072520 | Pride
Intervetebral disc degeneration lactylation sod1 
ProteomicsHDAC1 K412 lactylation acts as an intrinsic metabolic barrier against p53-dependent osteoblast apoptosis in glucocorticoid-induced osteoporosis
4D Label-free Lactylomics: Primary osteoblasts derived from Dex- or Dex/NaLa-treated mice were lysed in lysis buffer containing 8 M urea and protease/phosphatase inhibitors. After reduction and alkylation, proteins were digested with trypsin overnight. Peptides were incubated with pan-anti-lactyllys...
ORGANISM(S): Mus Musculus 
2026-09-25 | PXD084853 |
ProteomicsMitochondrial protein lactylation in myocardial infarction
Lactylation, a novel post-translational modification (PTM), in which a lactyl group, derived from lactate, is covalently added to lysine residues on the target proteins. Lactylation, first observed in histones in 2019, is increasingly recognized for its influence on gene expression, especially as it...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD068087 | Pride
Lactate Mct1 Lactylation  mitochondria  myocardial infarction  azd3965 
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